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DC Field | Value | Language |
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dc.contributor.author | Lau, D | - |
dc.contributor.author | Lechermann, LM | - |
dc.contributor.author | Gallagher, FA | - |
dc.date.accessioned | 2024-07-25T19:03:46Z | - |
dc.date.available | 2024-07-25T19:03:46Z | - |
dc.date.issued | 2021-10-12 | - |
dc.identifier | ORCiD: Doreen Lau https://orcid.org/0000-0002-7623-2401 | - |
dc.identifier.citation | Lau, D., Lechermann, L.M. and Gallagher, F.A. (2021) 'Clinical Translation of Neutrophil Imaging and Its Role in Cancer', Molecular Imaging and Biology, 24 (2), pp. 221 - 234. doi. 10.1007/s11307-021-01649-2. | en_US |
dc.identifier.issn | 1536-1632 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29414 | - |
dc.description | Supplementary Information is available online at: https://link.springer.com/article/10.1007/s11307-021-01649-2#Sec15 . | en_US |
dc.description.abstract | Neutrophils are the first line of defense against pathogens and abnormal cells. They regulate many biological processes such as infections and inflammation. Increasing evidence demonstrated a role for neutrophils in cancer, where different subpopulations have been found to possess both pro- or anti-tumorigenic functions in the tumor microenvironment. In this review, we discuss the phenotypic and functional diversity of neutrophils in cancer, their prognostic significance, and therapeutic relevance in human and preclinical models. Molecular imaging methods are increasingly used to probe neutrophil biology in vivo, as well as the cellular changes that occur during tumor progression and over the course of treatment. This review will discuss the role of neutrophil imaging in oncology and the lessons that can be drawn from imaging in infectious diseases and inflammatory disorders. The major factors to be considered when developing imaging techniques and biomarkers for neutrophils in cancer are reviewed. Finally, the potential clinical applications and the limitations of each method are discussed, as well as the challenges for future clinical translation. | en_US |
dc.description.sponsorship | The researchers are funded by Cancer Research UK (CRUK) (C19212/A16628, C19212/A911376), the CRUK Cambridge Centre (C9685/A25177), a Cambridge Commonwealth, European and International Trust PhD Scholarship, the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (RG85317), and GlaxoSmithKline. | en_US |
dc.format.extent | 221 - 234 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | BMC (part of Springer Nature) | en_US |
dc.rights | Copyright © 2024 The Author(s) Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | neutrophils | en_US |
dc.subject | cancer | en_US |
dc.subject | infection | en_US |
dc.subject | inflammation | en_US |
dc.title | Clinical Translation of Neutrophil Imaging and Its Role in Cancer | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2021-08-31 | - |
dc.identifier.doi | https://doi.org/10.1007/s11307-021-01649-2 | - |
dc.relation.isPartOf | Molecular Imaging and Biology | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.volume | 24 | - |
dc.identifier.eissn | 1860-2002 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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