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DC Field | Value | Language |
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dc.contributor.author | Kakogiannos, N | - |
dc.contributor.author | Scalise, AA | - |
dc.contributor.author | Martini, E | - |
dc.contributor.author | Maderna, C | - |
dc.contributor.author | Benvenuto, AF | - |
dc.contributor.author | D’Antonio, M | - |
dc.contributor.author | Carmignani, L | - |
dc.contributor.author | Magni, S | - |
dc.contributor.author | Gullotta, GS | - |
dc.contributor.author | Lampugnani, MG | - |
dc.contributor.author | Iannelli, F | - |
dc.contributor.author | Beznoussenko, GV | - |
dc.contributor.author | Mironov, AA | - |
dc.contributor.author | Cerutti, C | - |
dc.contributor.author | Bentley, K | - |
dc.contributor.author | Philippides, A | - |
dc.contributor.author | Zanardi, F | - |
dc.contributor.author | Bacigaluppi, M | - |
dc.contributor.author | Sigismund, S | - |
dc.contributor.author | Bassani, C | - |
dc.contributor.author | Farina, C | - |
dc.contributor.author | Martino, G | - |
dc.contributor.author | De Giovanni, M | - |
dc.contributor.author | Dejana, E | - |
dc.contributor.author | Iannacone, M | - |
dc.contributor.author | Inverso, D | - |
dc.contributor.author | Giannotta, M | - |
dc.date.accessioned | 2024-08-05T14:58:15Z | - |
dc.date.available | 2024-08-05T14:58:15Z | - |
dc.date.issued | 2024-08-01 | - |
dc.identifier | ORCiD: Camilla Cerutti https://orcid.org/0000-0001-9426-686X | - |
dc.identifier | e165368 | - |
dc.identifier.citation | Kakogiannos, N. et al. (2024) 'GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system', Journal of Clinical Investigation, 134 (15), e165368, pp. 1 - 17. doi: 10.1172/jci165368. | en_US |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29507 | - |
dc.description | Data availability. RNA sequencing data are available through the European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI) ArrayExpress BioStudies portal with accession number E-MTAB-13914. All supporting data are provided in the Supporting Data Values file. | en_US |
dc.description.abstract | The blood-brain barrier (BBB) acquires unique properties to regulate neuronal function during development. The formation of the BBB, which occurs in tandem with angiogenesis, is directed by the Wnt/β-catenin signaling pathway. Yet the exact molecular interplay remains elusive. Our study reveals the G protein–coupled receptor GPR126 as a critical target of canonical Wnt signaling, essential for the development of the BBB’s distinctive vascular characteristics and its functional integrity. Endothelial cell–specific deletion of the Gpr126 gene in mice induced aberrant vascular morphogenesis, resulting in disrupted BBB organization. Simultaneously, heightened transcytosis in vitro compromised barrier integrity, resulting in enhanced vascular permeability. Mechanistically, GPR126 enhanced endothelial cell migration, pivotal for angiogenesis, acting through an interaction between LRP1 and β1 integrin, thereby balancing the levels of β1 integrin activation and recycling. Overall, we identified GPR126 as a specifier of an organotypic vascular structure, which sustained angiogenesis and guaranteed the acquisition of the BBB properties during development. | en_US |
dc.description.sponsorship | This study was supported by the European Research Council (ERC; 742922) and AIRC (18683 and 21320) to ED; ITN BtRAIN (675619) and CARIPLO Foundation (2016-0461) to MG; and AIRC (26183) and Horizon 2020 (964481) to DI. KB was funded by the Francis Crick Institute (FC001751). AP is funded by the Engineering and Physical Sciences Research Council (EP/S030964/1). SS was supported by the ERC (grant 101002280) and AIRC (grant 24415). MDG is supported by the Armenise Harvard Foundation, ERC (101116224), and AIRC (27564). MI is supported by the ERC (725038), AIRC (19891 and 22737), and Italian Ministry for University and Research (INF-ACT and PRIN 2022FMESXL). | en_US |
dc.format.extent | 1 - 17 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | American Society for Clinical Investigation | en_US |
dc.rights | Copyright © 2024 Kakogiannos et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2024-06-04 | - |
dc.identifier.doi | https://doi.org/10.1172/jci165368 | - |
dc.relation.isPartOf | Journal of Clinical Investigation | - |
pubs.issue | 15 | - |
pubs.publication-status | Published | - |
pubs.volume | 134 | - |
dc.identifier.eissn | 1558-8238 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | Kakogiannos et al. | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2024 Kakogiannos et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. | 16.42 MB | Adobe PDF | View/Open |
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