Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/29528
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cerutti, C | - |
dc.contributor.author | Ridley, AJ | - |
dc.date.accessioned | 2024-08-11T07:46:14Z | - |
dc.date.available | 2024-08-11T07:46:14Z | - |
dc.date.issued | 2017-06-08 | - |
dc.identifier.citation | Cerutti, C. and Ridley, A.J. (2017) 'Endothelial cell-cell adhesion and signaling', Experimental Cell Research, 2017, 358 (1), pp. 31 - 38. doi: 10.1016/j.yexcr.2017.06.003. | en_US |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29528 | - |
dc.description.abstract | Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration. | en_US |
dc.description.sponsorship | Organisations supporting research: Cancer Research UK grant no. C6620/A15961. | en_US |
dc.format.extent | 31 - 38 | - |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2017 The Authors. Published by Elsevier Inc. This is an open access article under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | endothelial cells | en_US |
dc.subject | adherens junctions | en_US |
dc.subject | tight junctions | en_US |
dc.subject | Rho | en_US |
dc.subject | GTPases | en_US |
dc.subject | Rap GTPases | en_US |
dc.subject | actin cytoskeleton | en_US |
dc.subject | cell signaling | en_US |
dc.title | Endothelial cell-cell adhesion and signaling | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2017-06-02 | - |
dc.identifier.doi | https://doi.org/10.1016/j.yexcr.2017.06.003 | - |
dc.relation.isPartOf | Experimental Cell Research | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 358 | - |
dc.identifier.eissn | 1090-2422 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright © 2017 The Authors. Published by Elsevier Inc. This is an open access article under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). | 789.14 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License