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http://bura.brunel.ac.uk/handle/2438/2959
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Meaburn, KJ | - |
dc.contributor.author | Levy, N | - |
dc.contributor.author | Toniolo, D | - |
dc.contributor.author | Bridger, JM | - |
dc.coverage.spatial | 3 | en |
dc.date.accessioned | 2009-01-15T17:48:24Z | - |
dc.date.available | 2009-01-15T17:48:24Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Biochemical Society Transactions. 33 ( 6) 1438-1440 | en |
dc.identifier.issn | 0300-5127 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/2959 | - |
dc.description.abstract | Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration and premature aging have been linked with mutations in lamin A or emerin. These are termed laminopathies, withmutations in emerin causing Emery–Dreifuss muscular dystrophy. Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected. | en |
dc.format.extent | 265568 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | Portland Press | en |
dc.title | Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations | en |
dc.type | Research Paper | en |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
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File | Description | Size | Format | |
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0331438.pdf | 259.34 kB | Adobe PDF | View/Open |
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