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DC Field | Value | Language |
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dc.contributor.author | Symonds, ALJ | - |
dc.contributor.author | Zheng, W | - |
dc.contributor.author | Miao, T | - |
dc.contributor.author | Wang, H | - |
dc.contributor.author | Wang, T | - |
dc.contributor.author | Kiome, R | - |
dc.contributor.author | Hou, X | - |
dc.contributor.author | Li, S | - |
dc.contributor.author | Wang, P | - |
dc.date.accessioned | 2024-09-10T07:19:39Z | - |
dc.date.available | 2024-09-10T07:19:39Z | - |
dc.date.issued | 2020-07-24 | - |
dc.identifier | ORCiD: Alistair L.J. Symonds https://orcid.org/0000-0002-9461-0816 | - |
dc.identifier | ORCiD: Wei Zheng https://orcid.org/0000-0002-1741-7537 | - |
dc.identifier | ORCiD: Xiujuan Hou https://orcid.org/0000-0002-1236-6849 | - |
dc.identifier | ORCiD: Suling Li https://orcid.org/0000-0001-8756-9336 | - |
dc.identifier | ORCiD: Ping Wang https://orcid.org/0000-0001-8992-1233 | - |
dc.identifier | e202000766 | - |
dc.identifier.citation | Symonds, A.L.J. et al. (2020) 'Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1<sup>high</sup> memory phenotype CD4 T cells', Life Science Alliance, 3 (9), e202000766, pp. 1 - 16. doi: 10.26508/LSA.202000766. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29694 | - |
dc.description | Data Availability: RNA-seq and ChIP-seq data are available from ArrayExpress under accession numbers E-MTAB-7795 and E-MTAB-7797, respectively, whereas TCR-seq data are available from the European Nucleotide Archive under study number PRJEB33211. | en_US |
dc.description.abstract | The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now found that the Egr2+ subset (PD-1high MP) of MP CD4 T cells expresses high levels of checkpoint molecules (PD-1 and Lag3) and also markers of effector T cells (CXCR3 and ICAM-1). Egr2/3 are not required for PD-1high MP CD4 cell development but mediate a unique transcriptional programme that effectively controls their inflammatory responses, while promoting homeostatic proliferation and adaptive responses. Egr2 negative PD-1high MP CD4 T cells are impaired in homeostatic proliferation and adaptive responses against viral infection but display inflammatory responses to innate stimulation such as IL-12. PD-1high MP CD4 T cells have recently been implicated in rheumatoid arthritis pathogenesis, and we have now found that Egr2 expression is reduced in PD-1high MP CD4 T cells from patients with active rheumatoid arthritis compared with healthy controls. These findings demonstrate that Egr2/3 control the inflammatory responses of PD-1high MP CD4 T cells and maintain their adaptive immune fitness. | en_US |
dc.description.sponsorship | This work was supported by the Medical Research Council, UK (MR/N00096X/1), Barts Charity (MGU0463), and National Science Foundation of China (81774275). | en_US |
dc.format.extent | 1 - 16 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Life Science Alliance (Cold Spring Harbor Laboratory Press, Rockefeller University Press, and EMBO Press) | en_US |
dc.rights | Copyright © 2020 Symonds et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1<sup>high</sup> memory phenotype CD4 T cells | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2020-07-10 | - |
dc.identifier.doi | https://doi.org/10.26508/LSA.202000766 | - |
dc.relation.isPartOf | Life Science Alliance | - |
pubs.issue | 9 | - |
pubs.publication-status | Published | - |
pubs.volume | 3 | - |
dc.identifier.eissn | 2575-1077 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | Symonds et al. | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2020 Symonds et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). | 2.87 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License