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DC Field | Value | Language |
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dc.contributor.author | Alkan, E | - |
dc.contributor.author | Kumari, V | - |
dc.contributor.author | Evans, SL | - |
dc.date.accessioned | 2024-09-11T15:25:27Z | - |
dc.date.available | 2024-09-11T15:25:27Z | - |
dc.date.issued | 2024-08-14 | - |
dc.identifier | ORCiD: Veena Kumari https://orcid.org/0000-0002-9635-5505 | - |
dc.identifier | ORCiD: Simon L. Evans https://orcid.org/0000-0001-7875-9445 | - |
dc.identifier.citation | Alkan, E., Kumari, V. and Evans, S.L. (2024) 'Frontal brain volume correlates of impaired executive function in schizophrenia', Journal of Psychiatric Research, 178, pp. 397 - 404. doi: 10.1016/j.jpsychires.2024.08.018. | en_US |
dc.identifier.issn | 0022-3956 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29708 | - |
dc.description | Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request. | en_US |
dc.description | Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S0022395624004680?via%3Dihub#appsec1 . | - |
dc.description.abstract | Cognitive impairments affect functional capacity in individuals with schizophrenia (SZH), but their neural basis remains unclear. The Wisconsin Card Sorting Test (WCST), and the Stroop Task (SCWT), are paradigmatic tests which have been used extensively for examining executive function in SZH. However, few studies have explored how deficits on these tasks link to brain volume differences commonly seen in SZH. Here, for the first time, we tested associations between FreeSurfer-derived frontal brain volumes and performance on both WCST and SCWT, in a well-matched sample of 57 SZH and 32 control subjects. We also explored whether these associations were dissociable from links to symptom severity in SZH. Results revealed correlations between volumes and task performance which were unique to SZH. In SZH only, volumes of right middle frontal regions correlated with both WCST and Stroop performance: correlation coefficients were significantly different to those present in the control group, highlighting their specificity to the patient group. In the Stroop task, superior frontal regions also showed associations with Stroop interference scores which were unique to SZH. These findings provide important detail around how deficits on these two paradigmatic executive function tasks link to brain structural differences in SZH. Results align with converging evidence suggesting that neuropathology within right middle frontal regions (BA9 and BA46) might be of particular import in SZH. No volumetric associations with symptom severity were found, supporting the notion that the structural abnormalities underpinning cognitive deficits in SZH differ from those associated with symptomatology. | en_US |
dc.description.sponsorship | The study was supported by funds from the Wellcome Trust, UK (067427/z/02/z). | en_US |
dc.format.extent | 397 - 404 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | schizophrenia | en_US |
dc.subject | executive function | en_US |
dc.subject | stroop | en_US |
dc.subject | WCST | en_US |
dc.subject | cognition | en_US |
dc.subject | MRI | en_US |
dc.subject | brain volume | en_US |
dc.subject | psychosis | en_US |
dc.subject | decision making | en_US |
dc.subject | frontal lobe | en_US |
dc.subject | inhibition | en_US |
dc.subject | inhibitory control | en_US |
dc.subject | brain structure | en_US |
dc.subject | Wisconsin | en_US |
dc.title | Frontal brain volume correlates of impaired executive function in schizophrenia | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2024-08-13 | - |
dc.identifier.doi | https://doi.org/10.1016/j.jpsychires.2024.08.018 | - |
dc.relation.isPartOf | Journal of Psychiatric Research | - |
pubs.publication-status | Published | - |
pubs.volume | 178 | - |
dc.identifier.eissn | 1879-1379 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | 1.87 MB | Adobe PDF | View/Open |
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