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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/29842
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dc.contributor.authorMitolo, M-
dc.contributor.authorLombardi, G-
dc.contributor.authorManca, R-
dc.contributor.authorNacmias, B-
dc.contributor.authorVenneri, A-
dc.date.accessioned2024-09-29T11:36:07Z-
dc.date.available2024-09-29T11:36:07Z-
dc.date.issued2024-09-12-
dc.identifierORCiD: Riccardo Manca https://orcid.org/0000-0003-1715-6442-
dc.identifierORCiD: Annalena Venneri annalena.venneri@brunel.ac.uk-
dc.identifier.citationMitolo, M. et al. (2024) 'Association between blood-based protein biomarkers and brain MRI in the Alzheimer’s disease continuum: a systematic review', Journal of Neurology, 0 (ahead of print), pp. 1 - 21. doi: 10.1007/s00415-024-12674-w.en_US
dc.identifier.issn0340-5354-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/29842-
dc.descriptionSupplementary Information is available online at: https://link.springer.com/article/10.1007/s00415-024-12674-w#Sec15 .-
dc.description.abstractBlood-based biomarkers (BBM) are becoming easily detectable tools to reveal pathological changes in Alzheimer’s disease (AD). A comprehensive and up-to-date overview of the association between BBM and brain MRI parameters is not available. This systematic review aimed to summarize the literature on the associations between the main BBM and MRI markers across the clinical AD continuum. A systematic literature search was carried out on PubMed and Web of Science and a total of 33 articles were included. Hippocampal volume was positively correlated with Aβ42 and Aβ42/Aβ40 and negatively with Aβ40 plasma levels. P-tau181 and p-tau217 concentrations were negatively correlated with temporal grey matter volume and cortical thickness. NfL levels were negatively correlated with white matter microstructural integrity, whereas GFAP levels were positively correlated with myo-inositol values in the posterior cingulate cortex/precuneus. These findings highlight consistent associations between various BBM and brain MRI markers even in the pre-clinical and prodromal stages of AD. This suggests a possible advantage in combining multiple AD-related markers to improve accuracy of early diagnosis, prognosis, progression monitoring and treatment response.en_US
dc.description.sponsorshipThis research was supported by funding obtained under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3—Call for tender No. 341 of 15/03/2022 of the Italian Ministry of University and Research funded by the European Union—NextGenerationEU, Project code PE0000006, Concession Decree No. 1553 of 11/10/2022 adopted by the Italian Ministry of University and Research, CUP D93C22000930002, “A multiscale integrated approach to the study of the nervous system in health and disease” (MNESYS).en_US
dc.format.extent1 - 21-
dc.format.mediumPrint-Electronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.rightsCopyright © The Author(s) 2024. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAlzheimer’s diseaseen_US
dc.subjectblood-based biomarkersen_US
dc.subjectMRIen_US
dc.subjectdementiaen_US
dc.subjectmild cognitive impairmenten_US
dc.subjectsubjective cognitive declineen_US
dc.titleAssociation between blood-based protein biomarkers and brain MRI in the Alzheimer’s disease continuum: a systematic reviewen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1007/s00415-024-12674-w-
dc.relation.isPartOfJournal of Neurology-
pubs.issue00-
pubs.publication-statusPublished-
pubs.volume0-
dc.identifier.eissn1432-1459-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Life Sciences Research Papers

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