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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/30367
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dc.contributor.authorWood, GK-
dc.contributor.authorSargent, BF-
dc.contributor.authorAhmad, Z-U-A-
dc.contributor.authorTharmaratnam, K-
dc.contributor.authorDunai, C-
dc.contributor.authorEgbe, FN-
dc.contributor.authorMartin, NH-
dc.contributor.authorFacer, B-
dc.contributor.authorPendered, SL-
dc.contributor.authorRogers, HC-
dc.contributor.authorHübel, C-
dc.contributor.authorvan Wamelen, DJ-
dc.contributor.authorBethlehem, RAI-
dc.contributor.authorGiunchiglia, V-
dc.contributor.authorHellyer, PJ-
dc.contributor.authorTrender, W-
dc.contributor.authorKalsi, G-
dc.contributor.authorNeedham, E-
dc.contributor.authorEaston, A-
dc.contributor.authorJackson, TA-
dc.contributor.authorCunningham, C-
dc.contributor.authorUpthegrove, R-
dc.contributor.authorPollak, TA-
dc.contributor.authorHotopf, M-
dc.contributor.authorSolomon, T-
dc.contributor.authorPett, SL-
dc.contributor.authorShaw, PJ-
dc.contributor.authorWood, N-
dc.contributor.authorHarrison, NA-
dc.contributor.authorMiller, KL-
dc.contributor.authorJezzard, P-
dc.contributor.authorWilliams, G-
dc.contributor.authorDuff, EP-
dc.contributor.authorWilliams, S-
dc.contributor.authorZelaya, F-
dc.contributor.authorSmith, SM-
dc.contributor.authorKeller, S-
dc.contributor.authorBroome, M-
dc.contributor.authorKingston, N-
dc.contributor.authorHusain, M-
dc.contributor.authorVincent, A-
dc.contributor.authorBradley, J-
dc.contributor.authorChinnery, P-
dc.contributor.authorMenon, DK-
dc.contributor.authorAggleton, JP-
dc.contributor.authorNicholson, TR-
dc.contributor.authorTaylor, JP-
dc.contributor.authorDavid, AS-
dc.contributor.authorCarson, A-
dc.contributor.authorBullmore, E-
dc.contributor.authorBreen, G-
dc.contributor.authorHampshire, A-
dc.contributor.authorZandi, MS-
dc.contributor.authorWong, SH-
dc.contributor.authorVenneri, A-
dc.contributor.authorVeenith, T-
dc.contributor.authorUnderwood, J-
dc.contributor.authorThomson, E-
dc.contributor.authorThomas, RH-
dc.contributor.authorTamborska, A-
dc.contributor.authorTaams, L-
dc.contributor.authorSmith, J-
dc.contributor.authorSmith, CJ-
dc.contributor.authorSingh, B-
dc.contributor.authorSieradzki, A-
dc.contributor.authorShil, RSK-
dc.contributor.authorSemple, S-
dc.contributor.authorSeed, AW-
dc.contributor.authorSawcer, SJ-
dc.contributor.authorSamuel, M-
dc.contributor.authorSalman, RAS-
dc.contributor.authorRota, S-
dc.contributor.authorRoberts, A-
dc.contributor.authorPeacock, S-
dc.contributor.authorPatel, A-
dc.contributor.authorPalmos, A-
dc.contributor.authorOstermann, M-
dc.contributor.authorOrazulume, O-
dc.contributor.authorO’Malley, R-
dc.contributor.authorNicholas, N-
dc.contributor.authorNewcombe, V-
dc.contributor.authorNair, A-
dc.contributor.authorMulholland, C-
dc.contributor.authorMorris, CM-
dc.contributor.authorMonssen, D-
dc.contributor.authorMcIntosh, AM-
dc.contributor.authorMcIlwaine, R-
dc.contributor.authorMcKeever, S-
dc.contributor.authorMcGlinchey, E-
dc.contributor.authorMcDonnell, G-
dc.contributor.authorMansoori, P-
dc.contributor.authorMadarshahian, D-
dc.contributor.otherCOVID-CNS Consortium-
dc.date.accessioned2024-12-23T12:09:04Z-
dc.date.available2024-12-23T12:09:04Z-
dc.date.issued2024-09-23-
dc.identifierORCiD: Greta K. Wood https://orcid.org/0000-0001-6098-2331-
dc.identifierORCiD: Brendan F. Sargent https://orcid.org/0000-0003-2262-7755-
dc.identifierORCiD: Zain-Ul-Abideen Ahmad https://orcid.org/0000-0002-6940-8851-
dc.identifierORCiD: Kukatharmini Tharmaratnam https://orcid.org/0000-0002-8255-9822-
dc.identifierORCiD: Benedict D. Michael https://orcid.org/0000-0002-8693-8926-
dc.identifierORCiD: Annalena Venneri https://orcid.org/0000-0002-9488-2301-
dc.identifier.citationWood, K. et al. on behalf of the COVID-CNS Consortium (2024) 'Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction', Nature Medicine, 0 (ahead of print), pp. 1 - 25. doi: 10.1038/s41591-024-03309-8.en_US
dc.identifier.issn1078-8956-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/30367-
dc.descriptionData availability: Individual-level data and samples from the COVID-Clinical Neuroscience Study are available for collaborative research by application through the NIHR BioResource Data Access Committee https://bioresource.nihr.ac.uk/using-our-bioresource/apply-for-bioresource-data-access/. The Committee decide on academic applications, with escalation to the NIHR BioResource Steering Committee for contentious applications, and/or applications from industry. Participants in the NIHR BioResource have all consented to the sharing of de-identified data with bona fide researchers worldwide, for research in the public interest. There are limits to these consents both by expectation and legal—some datasets may not be shared beyond a safe setting in the UK. The Data Access Committee aim to process data-only requests as quickly as possible and meet fortnightly to consider applications. Once approved, timeframes for data availability vary from 2 weeks to 6 months depending on the nature of the data requested.en_US
dc.descriptionCode availability: Code is publicly available via https://github.com/tnggroup/covidcns.-
dc.descriptionExtended data are available online at: https://www.nature.com/articles/s41591-024-03309-8#Sec24 .-
dc.descriptionSupplementary information is available online at: https://www.nature.com/articles/s41591-024-03309-8#Sec25 .-
dc.description.abstractThe spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.en_US
dc.description.sponsorshipMembers of the COVID-CNS Study Group are supported to conduct COVID-19 neuroscience research by the UK Research and Innovation/Medical Research Council (UKRI/MRC; grant no. MR/V03605X/1). G.K.W. is funded by the UK NIHR as an NIHR Academic Clinical Fellow (ACF-2022-07-007). B.D.M., G.B. and other investigators are supported by NIHR Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool, NIHR/Wellcome Trust King’s Clinical Research Facility, NIHR Maudsley Biomedical Research Centre at South London, Maudsley NHS Foundation Trust and King’s College London. B.D.M. is also supported for additional neurological inflammation research due to viral infection by grants from: the NIHR (award CO-CIN-01), the MRC (MC_PC_19059), the UKRI/MRC (MR/V007181/1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3). J.-P.T. is supported by the Newcastle NIHR Biomedical Research Centre and the NIHR Dementia Translational Research Collaboration. This publication was supported by the Association of British Neurologists, British Paediatric Neurology Association, British Association of Stroke Physicians and the Royal College of Psychiatrists.en_US
dc.format.extent1 - 25-
dc.format.mediumPrint-Electronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.urihttps://github.com/tnggroup/covidcns-
dc.rightsAttribution 4.0 International-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectchronic inflammationen_US
dc.subjectencephalopathyen_US
dc.subjectoutcomes researchen_US
dc.subjectpredictive markersen_US
dc.subjectviral infectionen_US
dc.titlePosthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reductionen_US
dc.typeArticleen_US
dc.date.dateAccepted2024-09-18-
dc.identifier.doihttps://doi.org/10.1038/s41591-024-03309-8-
dc.relation.isPartOfNature Medicine-
pubs.issueahead of print-
pubs.publication-statusPublished-
pubs.volume0-
dc.identifier.eissn1546-170X-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Life Sciences Research Papers

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