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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/30547
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dc.contributor.authorManca, R-
dc.contributor.authorDe Marco, M-
dc.contributor.authorSoininen, H-
dc.contributor.authorRuffini, L-
dc.contributor.authorVenneri, A-
dc.date.accessioned2025-01-22T16:00:37Z-
dc.date.available2025-01-22T16:00:37Z-
dc.date.issued2025-01-10-
dc.identifierORCiD: Riccardo Manca https://orcid.org/0000-0003-1715-6442-
dc.identifierORCiD: Matteo De Marco https://orcid.org/0000-0002-9240-8067-
dc.identifierORCiD: Annalena Venneri https://orcid.org/0000-0002-9488-2301-
dc.identifierfcaf008-
dc.identifier.citationManca, R. et al. (2025) 'Changes in neurotransmitter-related functional connectivity along the Alzheimer’s disease continuum', Brain Communications, 2025, 0 (ahead of print), fcaf008, pp. 1 - 39. doi: 10.1093/braincomms/fcaf008.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/30547-
dc.descriptionData availability: The data supporting the findings of this study are available from the corresponding author, upon reasonable request. The dataset used in this study was collected as part of a project supported by funding from the European Union Seventh Framework Program (FP7/2007e2013) under grant agreement no. 601055, Virtual Physiological Human: DementiA RESearch Enabled by IT (VPH-DARE@IT) to AV and HS.en_US
dc.descriptionAccepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.-
dc.description.abstractAlzheimer’s disease (AD) may be associated with early dopamine (DA) dysfunction. However, its effects on neurofunctional alterations in the neurotransmission pathways remain elusive. In this study, PET atlases and functional MRI data for 86 older adults with mild cognitive impairment (AD-MCI), 58 with mild AD dementia and 76 cognitively unimpaired (CU) were combined to investigate connectivity alterations associated with the dopaminergic and cholinergic (ACh) systems. A cross-sectional design was used to compare neurotransmitter-related functional connectivity across groups and associations between functional connectivity and cognitive performance. The findings show that the AD-dementia group showed a decline in mesocorticolimbic DA-related connectivity in the precuneus but heightened connectivity in the thalamus, whereas the AD-MCI group showed a decline in nigrostriatal connectivity in the left temporal areas. ACh-related connectivity decline was observed in both AD-MCI and AD-dementia primarily in the temporo-parietal areas. Episodic memory scores correlated positively with ACh- and DA-related connectivity in the temporo-parietal cortex and negatively with DA-related FC in the fronto-thalamic areas. This study shows that connectivity alterations in ACh and DA functional pathways parallel cognitive decline in AD and might be a clinically relevant marker in early AD.en_US
dc.description.sponsorshipThis work was supported by funding from the Excellent Science 2022 call of the University of Parma under the Fund for the Promotion and Development of the Policies of the National Research Programme awarded to AV. AV and RM are supported by funding obtained under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15/03/2022 of Italian Ministry of University and Research funded by the European Union – NextGenerationEU, Project code PE0000006, Concession Decree No. 1553 of 11/10/2022 adopted by the Italian Ministry of University and Research, CUP D93C22000930002, “A multiscale integrated approach to the study of the nervous system in health and disease” (MNESYS).en_US
dc.format.extent1 - 39-
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherOxford University Press on behalf of the Guarantors of Brainen_US
dc.rightsAttribution 4.0 International-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAlzheimer’s diseaseen_US
dc.subjectneurotransmittersen_US
dc.subjectfunctional connectivityen_US
dc.subjectPETen_US
dc.subjectMRIen_US
dc.titleChanges in neurotransmitter-related functional connectivity along the Alzheimer’s disease continuumen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1093/braincomms/fcaf008-
dc.relation.isPartOfBrain Communications-
pubs.issue00-
pubs.publication-statusPublished online-
pubs.volume0-
dc.identifier.eissn2632-1297-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dcterms.dateAccepted2025-01-09-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Life Sciences Research Papers

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