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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/30892
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dc.contributor.authorHarvey, J-
dc.contributor.authorSmith, AR-
dc.contributor.authorWeymouth, LS-
dc.contributor.authorSmith, RG-
dc.contributor.authorCastanho, I-
dc.contributor.authorHubbard, L-
dc.contributor.authorCreese, B-
dc.contributor.authorBresner, C-
dc.contributor.authorWilliams, N-
dc.contributor.authorPishva, E-
dc.contributor.authorLunnon, K-
dc.date.accessioned2025-03-11T08:43:34Z-
dc.date.available2025-03-11T08:43:34Z-
dc.date.issued2025-03-02-
dc.identifierORCiD: Joshua Harvey https://orcid.org/0000-0001-6423-9983-
dc.identifierORCiD: Luke S. Weymouth https://orcid.org/0000-0002-1168-6015-
dc.identifierORCiD: Rebecca G. Smith https://orcid.org/0000-0001-9264-1056-
dc.identifierORCiD: Byron Creese https://orcid.org/0000-0001-6490-6037-
dc.identifierORCiD: Catherine Bresner https://orcid.org/0000-0003-2673-9762-
dc.identifierORCiD: Nigel Williams https://orcid.org/0000-0003-1177-6931-
dc.identifierArticle no. 39-
dc.identifier.citationHarvey, J.et al. (2025) 'Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis',npj Parkinson's Disease, 11 (1), 39, pp. 1 - 10. doi:10.1038/s41531-025-00877-5.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/30892-
dc.descriptionData availability: DNA methylation data used in this study was provided for the study by the authors of a previous publication45. It is available via figshare https://doi.org/10.17035/cardiff.27195645.v1. Data used in the preparation of this article were obtained on 1st June 2020 from the Parkinson’s Progression Markers Initiative (PPMI) database (https://www.ppmi-info.org/access-data-specimens/download-data), RRID:SCR_006431. This analysis used data openly available from PPMI. For up-to-date information on the study, visit http://www.ppmi-info.org.en_US
dc.descriptionCode availability: All codes are available at https://github.com/JoshHarveyGit/PD_TraitNetworkAnalysis.-
dc.descriptionSupplementary information is available online at: https://www.nature.com/articles/s41531-025-00877-5#Sec18 .-
dc.description.abstractParkinson’s disease is a highly heterogeneous disorder, encompassing a complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We aimed to investigate genome-wide DNA methylation networks in post-mortem Parkinson’s disease brain samples and test for region-specific association with common neuropsychiatric and cognitive symptoms. Of traits tested, we identify a co-methylation module in the substantia nigra with significant correlation to depressive symptoms. Notably, expression of the genes annotated to the methylation loci present within this module are found to be significantly enriched in neuronal subtypes within the substantia nigra. These findings highlight the potential involvement of neuronal-specific changes within the substantia nigra with regards to depressive symptoms in Parkinson’s disease.en_US
dc.description.sponsorshipThis work was funded by research grants from the Medical Research Council (MRC (MR/S011625/1), the National Institute of Aging (NIA) of the National Institutes of Health (NIH) (R01AG067015), BRACE and the Charles Wolfson Charitable Trust to KL and from Parkinson’s UK (Project Grants G-1309 and G-1502) to NW. This study was supported by the National Institute for Health and Care Research Exeter Biomedical Research Centre.en_US
dc.format.extent1 - 10-
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution 4.0 International-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectepigeneticsen_US
dc.subjectgene regulatory networksen_US
dc.subjectParkinson's diseaseen_US
dc.titleEpigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysisen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1038/s41531-025-00877-5-
dc.relation.isPartOfnpj Parkinson's Disease-
pubs.issue1-
pubs.publication-statusPublished online-
pubs.volume11-
dc.identifier.eissn2373-8057-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dcterms.dateAccepted2025-01-24-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Life Sciences Research Papers

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