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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/32757
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dc.contributor.authorIkhile, D-
dc.contributor.authorHighton, P-
dc.contributor.authorGillies, C-
dc.contributor.authorAbdala, R-
dc.contributor.authorArdavani, A-
dc.contributor.authorArora, M-
dc.contributor.authorBanstola, A-
dc.contributor.authorBrahmbhatt, A-
dc.contributor.authorCassambai, S-
dc.contributor.authorFunnell, MP-
dc.contributor.authorGoenka, S-
dc.contributor.authorJeffers, S-
dc.contributor.authorKondal, D-
dc.contributor.authorMohan, S-
dc.contributor.authorMulakalapalli, P-
dc.contributor.authorOli, N-
dc.contributor.authorPeace, A-
dc.contributor.authorSingh, K-
dc.contributor.authorVaidya, A-
dc.contributor.authorVenkateshmurthy, NS-
dc.contributor.authorPrabhakaran, D-
dc.contributor.authorKhunti, K-
dc.date.accessioned2026-01-29T20:31:28Z-
dc.date.available2026-01-29T20:31:28Z-
dc.date.issued2026-01-26-
dc.identifierORCiD: Deborah Ikhile https://orcid.org/0000-0002-4343-1674-
dc.identifierORCiD: Patrick Highton https://orcid.org/0000-0002-0410-5788-
dc.identifierORCiD: Ashkon Ardavani https://orcid.org/0000-0002-9442-3295-
dc.identifierORCiD: Monika Arora https://orcid.org/0000-0001-9987-3933-
dc.identifierORCiD: Amrit Banstola https://orcid.org/0000-0003-3185-9638-
dc.identifierORCiD: Shabana Cassambai https://orcid.org/0000-0001-6201-9063-
dc.identifierORCiD: Mark P. Funnell https://orcid.org/0000-0001-7473-5999-
dc.identifierORCiD: Shifalika Goenka https://orcid.org/0000-0001-6993-2883-
dc.identifierORCiD: Shavez Jeffers https://orcid.org/0000-0001-7542-1772-
dc.identifierORCiD: Prakash Mulakalapalli https://orcid.org/0009-0000-9303-4741-
dc.identifierORCiD: Arron Peace https://orcid.org/0009-0005-3859-2907-
dc.identifierORCiD: Kuldeep Singh https://orcid.org/0000-0002-9375-3233-
dc.identifierORCiD: Nikhil Srinivasapura Venkateshmurthy https://orcid.org/0000-0003-4037-6371-
dc.identifierORCiD: Dorairaj Prabhakaran https://orcid.org/0000-0002-3172-834X-
dc.identifier.citationIkhile D. et al. (2026) 'Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis', Nature Communications, 0 (ahead of print), pp. 1 - x. doi: 10.1038/s41467-025-68197-z.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/32757-
dc.descriptionData availability: The data informing from this review are extracted from previously published studies in the public domain. The dataset generated and analysed during the review is available on Figshare repository (https://doi.org/10.25392/leicester.data.30156316.v1).en_US
dc.description"We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply."-
dc.descriptionSupplementary information is available online at: https://www.nature.com/articles/s41467-025-68197-z#Sec16 .-
dc.description.abstractThis review systematically synthesised the evidence on quality of life measures and outcomes for people living with multiple long-term conditions in the Southeast Asia region. Results were analysed using a combination of methods, meta-analysis for studies where the same quality of life score was reported across three or more cohorts, and descriptive narrative synthesis. In total, 34 studies comprising 11,876 participants were included in the narrative synthesis and 14 of these were included in meta-analysis. The most common quality of life tools used included WHOQOL-BREF ( <i>n</i>  =  8) and EQ-5D-5L ( <i>n</i>  =  3) with pooled mean values of 70.47 (95% CI: 62.71 to 78.24) and 0.76 (95% CI: 0.67 to 0.84) respectively, indicating reduced but good quality of life. As healthcare systems adapt to the evolving challenges associated with multiple long-term conditions, understanding the tools and measures used to assess quality of life in different contexts becomes imperative to account for disease combinations and cultural nuances.en_US
dc.description.sponsorshipThis research was funded by the NIHR Global Health Research Centre for Multiple Long-Term Conditions using UK aid from the UK Government to support global health research (NIHR203257). The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the UK government. K.K. is supported by the National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands (ARC EM), NIHR Global Research Centre for Multiple Long-Term Conditions, NIHR Cross NIHR Collaboration for Multiple Long-Term Conditions, NIHR Leicester Biomedical Research Centre (BRC) and the British Heart Foundation (BHF) Centre of Excellence. M.P.F., D.I., S.C., S.J. and A.P. are supported by the NIHR Applied Research Collaboration East Midlands (ARC EM). P.H. and R.A. are supported by an Advanced Research Fellowship award from the National Institute of Health and Care Research (NIHR303176). S.C. is supported by the supported by the National Institute for Health Research (NIHR) Global Health Research Group for Cardiometabolic Disease Research in Africa Partnership (CREATE) (NIHR132995).en_US
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsCreative Commons Attribution 4.0 International-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectoutcomes researchen_US
dc.subjectquality of lifeen_US
dc.titleQuality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.date.dateAccepted2025-12-16-
dc.identifier.doihttps://doi.org/10.1038/s41467-025-68197-z-
dc.relation.isPartOfNature Communications-
pubs.publication-statusPublished online-
dc.identifier.eissn2041-1723-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dcterms.dateAccepted2025-12-16-
dc.rights.holderThe Author(s)-
dc.contributor.orcidIkhile, Deborah [0000-0002-4343-1674]-
dc.contributor.orcidHighton, Patrick [0000-0002-0410-5788]-
dc.contributor.orcidArdavani, Ashkon [0000-0002-9442-3295]-
dc.contributor.orcidArora, Monika [0000-0001-9987-3933]-
dc.contributor.orcidBanstola, Amrit [0000-0003-3185-9638]-
dc.contributor.orcidCassambai, Shabana [0000-0001-6201-9063]-
dc.contributor.orcidFunnell, Mark P. [0000-0001-7473-5999]-
dc.contributor.orcidGoenka, Shifalika [0000-0001-6993-2883]-
dc.contributor.orcidJeffers, Shavez [0000-0001-7542-1772]-
dc.contributor.orcidMulakalapalli, Prakash [0009-0000-9303-4741]-
dc.contributor.orcidPeace, Arron [0009-0005-3859-2907]-
dc.contributor.orcidSingh, Kuldeep [0000-0002-9375-3233[-
dc.contributor.orcidVenkateshmurthy, Nikhil Srinivasapura [0000-0003-4037-6371]-
dc.contributor.orcidPrabhakaran, Dorairaj [0000-0002-3172-834X]-
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