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DC Field | Value | Language |
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dc.contributor.author | Anderson, PO | - |
dc.contributor.author | Manzo, BA | - |
dc.contributor.author | Sundstedt, A | - |
dc.contributor.author | Minaee, S | - |
dc.contributor.author | Symonds, A | - |
dc.contributor.author | Khalid, S | - |
dc.contributor.author | Rodriguez-Cabezas, ME | - |
dc.contributor.author | Nicolson, K | - |
dc.contributor.author | Li, S | - |
dc.contributor.author | Wraith, DC | - |
dc.contributor.author | Wang, P | - |
dc.date.accessioned | 2011-07-29T08:57:10Z | - |
dc.date.available | 2011-07-29T08:57:10Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | European Journal of Immunology 36(6): 1374 - 1385, Jun 2006 | en_US |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/5677 | - |
dc.description | This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2006 Wiley-Blackwell. | en_US |
dc.description.abstract | Repetitive antigen stimulation induces peripheral T cell tolerance in vivo. It is not known, however, whether multiple stimulations merely suppress T cell activation or, alternatively, change the transcriptional program to a distinct, tolerant state. In this study, we have discovered that STAT3 and STAT5 were activated in response to antigen stimulation in vivo, in marked contrast to the suppression of AP-1, NF-kappaB and NFAT. In addition, a number of transcription factors were induced in tolerant T cells following antigen challenge in vivo, including T-bet, Irf-1 and Egr-2. The altered transcription program in tolerant cells associates closely with the suppression of cell cycle progression and IL-2 production, as well as with the induction of IL-10. Studies of T-bet and Egr-2 show that the function of T-bet in peptide treatment-induced regulatory T cells is not associated with Th1 differentiation, but correlates with the suppression of IL-2, whereas expression of Egr-2 led to an up-regulation of the cell cycle inhibitors p21(cip1) and p27(kip). Our results demonstrate a balanced transcription program regulated by different transcription factors for T cell activation and/or tolerance during antigen-induced T cell responses. Persistent antigen stimulation can induce T cell tolerance by changing the balance of transcription factors. | en_US |
dc.description.sponsorship | This work was supported by a Programme Grant from the Wellcome Trust, Swedish Strategic Research fund, Barts Foundation for Research Limited and Brunel University. | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | Animals | en_US |
dc.subject | Cell cycle | en_US |
dc.subject | Cell nucleus | en_US |
dc.subject | Cyclin-dependent kinase inhibitor p21 | en_US |
dc.subject | Cyclin-dependent kinase inhibitor p27 | en_US |
dc.subject | Early growth response protein 2 | en_US |
dc.subject | Epitopes, T-Lymphocyte | en_US |
dc.subject | Gene expression profiling | en_US |
dc.subject | Gene expression regulation | en_US |
dc.subject | Immune tolerance | en_US |
dc.subject | Interleukin-2 | en_US |
dc.subject | Lymphocyte activation | en_US |
dc.subject | Mice | en_US |
dc.subject | Mice, transgenic | en_US |
dc.subject | Oligonucleotide array sequence analysis | en_US |
dc.subject | RNA | en_US |
dc.subject | Reverse transcriptase polymerase chain reaction | en_US |
dc.subject | Signal transduction | en_US |
dc.subject | T-box domain proteins | en_US |
dc.subject | T-Lymphocytes, Regulatory | en_US |
dc.subject | Transcription factors | en_US |
dc.subject | Transcription, Genetic | en_US |
dc.subject | Transfection | en_US |
dc.title | Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance. | en_US |
dc.type | Research Paper | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/eji.200635883 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel (Active) | - |
pubs.organisational-data | /Brunel/Brunel (Active)/School of Health Science & Social Care | - |
pubs.organisational-data | /Brunel/Research Centres | - |
pubs.organisational-data | /Brunel/Research Centres/BICGP | - |
pubs.organisational-data | /Brunel/School of Health Sciences and Social Care | - |
pubs.organisational-data | /Brunel/School of Health Sciences and Social Care/BICGP | - |
Appears in Collections: | Biological Sciences Publications Dept of Life Sciences Research Papers |
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