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Title: Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis
Authors: Bridger, JM
Kill, IR
Keywords: Hutchinson–Gilford progeria syndrome;Apoptosis;Aging;Lamin A;Brunel Institute for Ageing Studies (BIAS)
Issue Date: 2004
Publisher: Elsevier
Citation: Experimental Gerontology 39: 717-724, May 2004
Abstract: Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease. We show here that cellular aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by a period of hyperproliferation and terminates with a large increase in the rate of apoptosis. The occurrence of cells with abnormal nuclear morphology reported by others is shown to be a result of cell division since the fraction of these abnormalities increases with cellular age. Similarly, the proportion of cells with an abnormal or absent A-type lamina increases with age. These data provide clues as to the cellular basis for premature aging in HGPS and support the view that cellular senescence and tissue homeostasis are important factors in the normal aging process.
Appears in Collections:Community Health and Public Health
Dept of Clinical Sciences Research Papers

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