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Title: Reward modulates spatial neglect
Authors: Malhotra, PA
Soto, D
Li, K
Russell, C
Issue Date: 2012
Publisher: BMJ Publishing Group Ltd.
Citation: Journal of Neurology, Neurosurgery and Psychiatry, Forthcoming, Oct 2012
Abstract: BACKGROUND: Reward has been shown to affect attention in healthy individuals, but there have been no studies addressing whether reward influences attentional impairments in patients with focal brain damage. METHODS: Using two novel variants of a widely-used clinical cancellation task, we assessed whether reward modulated impaired attention in 10 individuals with left neglect secondary to right hemisphere stroke. RESULTS: Reward exposure significantly reduced neglect, as measured by total targets found, left-sided targets found and centre of cancellation, across the patient group. Lesion analysis showed that lack of response to reward was associated with damage to the ipsilateral striatum. CONCLUSIONS: This is the first experimental evidence that reward can modulate attentional impairments following brain damage. These results have significant implications for the development of behavioural and pharmacological therapies for patients with attentional disorders.
Description: Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source are credited. The article was made available through the Brunel University Open Access Publishing Fund.
ISSN: 0022-3050
Appears in Collections:Publications
Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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