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Title: APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age
Authors: Bunce, D
Anstey, KJ
Cherbuin, N
Gautam, P
Sachdev, P
Easteal, S
Keywords: Age;Alzheimer's disease;APOE;Entorhinal cortex
Issue Date: 2012
Publisher: IOS Press
Citation: Journal of Alzheimer's Disease, 30(4): 935 - 942, 2012
Abstract: The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer's disease (AD) while, conversely, the ε2 allele offers protection. One of the brain structures exhibiting the earliest changes associated with the disease is the entorhinal cortex. We therefore investigated the volumes of the entorhinal cortex and other structures in the medial temporal lobe including the parahippocampal gyrus, temporal pole, and inferior, middle, and superior temporal cortices, in relation to APOE genotype. Our main objectives were to determine if (a) volumes systematically varied according to allele in a stepwise fashion, ε2 > ε3 > ε4, and (b) associations varied according to age. We investigate this association in 627 non-demented community-dwelling adults in middle age (44 to 48 years; n = 314) and older age (64 to 68 years; n = 313) who underwent structural MRI scans. We found no evidence of APOE-related variation in brain volumes in the age groups examined. We conclude that if a ε2 > ε3 > ε4 pattern in brain volumes does emerge in non-demented adults living in the community in old age, it is not until after the age of 68 years.
Description: Copyright © 2012 IOS Press
This article has been made available through the Brunel Open Access Publishing Fund.
ISSN: 1387-2877
Appears in Collections:Publications
Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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