Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/7711
Title: | An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity |
Authors: | Nayak, A Dodagatta-Marri, E Tsolaki, AG Kishore, U |
Keywords: | Hypersensitivity;Infection;Innate immunity;Macrophage;Pattern recognition receptor;Surfactant |
Issue Date: | 2012 |
Publisher: | Frontiers |
Citation: | Front Immunol, 3, 131, 2012 |
Abstract: | Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands on pathogens, allergens, and apoptotic cells, via C-terminal homotrimeric carbohydrate recognition domains, while the collagen region brings about the effector functions via its interaction with cell surface receptors. SP-A and SP-D deal with various pathogens, using a range of innate immune mechanisms such as agglutination/aggregation, enhancement of phagocytosis, and killing mechanisms by phagocytic cells and direct growth inhibition. SP-A and SP-D have also been shown to be involved in the control of pulmonary inflammation including allergy and asthma. Emerging evidence suggest that SP-A and SP-D are capable of linking innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. This review enumerates immunological properties of SP-A and SP-D inside and outside lungs and discusses their importance in human health and disease. |
Description: | PMCID: PMC3369187 |
URI: | http://www.ncbi.nlm.nih.gov/pubmed/22701116 http://bura.brunel.ac.uk/handle/2438/7711 |
DOI: | http://dx.doi.org/10.3389/fimmu.2012.00131 |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 917 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.