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DC Field | Value | Language |
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dc.contributor.author | Carter, SE | - |
dc.contributor.author | Faulkner, A | - |
dc.contributor.author | Rakobowchuk, M | - |
dc.date.accessioned | 2014-02-04T12:14:51Z | - |
dc.date.available | 2014-02-04T12:14:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Hypertension, 32(2), 339 - 351, 2014 | en_US |
dc.identifier.issn | 1473-5598 | - |
dc.identifier.uri | http://journals.lww.com/jhypertension/Fulltext/2014/02000/The_role_of_prostaglandin_and_antioxidant.20.aspx | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/7988 | - |
dc.description | This article is made available through the Brunel Open Access Publishing Fund. It is shared under the Creative Commons License Attribution-Noncommercial No Derivative 3.0 (CCBY NCND). Copyright @ Lippincott Williams & Wilkins. | en_US |
dc.description.abstract | Background: Endothelial dysfunction, manifesting as attenuated flow-mediated dilation (FMD), is clinically important. Antioxidants may prevent this dysfunction; however, the acute effects of oral administration in humans are unknown. Low flow-mediated constriction (L-FMC), a further parameter of endothelial health, is largely unstudied and the mechanisms for this response unclear. Methods: Twelve healthy participants (five women and seven men) completed three test conditions: control; antioxidant cocktail (α-lipoic acid, vitamins C and E); and prostaglandin inhibitor ingestion (ibuprofen). Ultrasound measurements of brachial artery responses were assessed throughout 5 min of forearm ischemia and 3 min after. Subsequently, an ischemia–reperfusion injury was induced by a 20-min upper arm occlusion. Further, vascular function protocols were completed at 15, 30, and 45 min of recovery. Results: Endothelial dysfunction was evident in all conditions. FMD was attenuated at 15 min after ischemia–reperfusion injury (Pre: 6.24 ± 0.58%; Post15: 0.24 ± 0.75%; mean ± SD, P < 0.05), but recovered by 45 min. Antioxidant administration did not preserve FMD compared with control (P > 0.05). The magnitude of L-FMC was augmented at 15 min (Pre: 1.44 ± 0.27%; Post15: 3.75 ± 1.73%; P < 0.05) and recovered by 45 min. Ibuprofen administration produced the largest constrictive response (Pre: −1.13 ± 1.71%; Post15: −5.57 ± 3.82%; time × condition interaction: P < 0.05). Conclusion: Results demonstrate ischemia–reperfusion injury causes endothelial dysfunction and acute oral antioxidant supplementation fails to reduce its magnitude. Our results also suggest that a lack of shear stress during occlusion combined with suppression of prostaglandin synthesis magnifies L-FMC, possibly due to augmented endothelin-1 expression. | en_US |
dc.description.sponsorship | Society of Biology | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.subject | Allometric scaling | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Flow-mediated dilation | en_US |
dc.subject | Ibuprofin | en_US |
dc.subject | Low flow-mediated constriction | en_US |
dc.subject | Shear rate | en_US |
dc.title | The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1097/HJH.0000000000000033 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Sport & Education | - |
Appears in Collections: | Sport Publications Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Fulltext.pdf | 1.73 MB | Adobe PDF | View/Open |
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