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DC Field | Value | Language |
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dc.contributor.author | Simpson, AJ | - |
dc.contributor.author | Tufvesson, E | - |
dc.contributor.author | Anderson, SD | - |
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Bjermer, L | - |
dc.contributor.author | Kippelen, P | - |
dc.date.accessioned | 2014-05-15T10:57:34Z | - |
dc.date.available | 2014-05-15T10:57:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Applied Physiology, 115(10), 1450 - 1456, 2013 | en_US |
dc.identifier.issn | 8750-7587 | - |
dc.identifier.uri | http://jap.physiology.org/content/115/10/1450 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8432 | - |
dc.description | This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication must be cited. | en_US |
dc.description.abstract | Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions (P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 ± 495 pg/μmol creatinine after placebo vs. 315 ± 523 pg/μmol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes. | en_US |
dc.description.sponsorship | World Anti Doping Agency | en_US |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | American Physiological Society | en_US |
dc.subject | Exercise-induced bronchoconstriction | en_US |
dc.subject | Epithelial injury | en_US |
dc.subject | Inhaled beta(2)-agonist | en_US |
dc.subject | Clara cell | en_US |
dc.title | Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1152/japplphysiol.00716.2013 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Sport & Education | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Sport & Education/Sport | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Sport and Education - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Sport and Education - URCs and Groups/Centre for Sports Medicine and Human Performance | - |
Appears in Collections: | Sport Publications Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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