Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/8725
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santilli, G | - |
dc.contributor.author | Piotrowska, I | - |
dc.contributor.author | Cantilena, S | - |
dc.contributor.author | Chayka, O | - |
dc.contributor.author | D'Alicarnasso, M | - |
dc.contributor.author | Morgenstern, DA | - |
dc.contributor.author | Himoudi, N | - |
dc.contributor.author | Pearson, K | - |
dc.contributor.author | Anderson, J | - |
dc.contributor.author | Thrasher, AJ | - |
dc.contributor.author | Sala, A | - |
dc.date.accessioned | 2014-07-21T10:12:23Z | - |
dc.date.available | 2014-07-21T10:12:23Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Clinical Cancer Research, 19(5), 1116 - 1125, 2013 | en_US |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | http://clincancerres.aacrjournals.org/content/19/5/1116 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8725 | - |
dc.description | This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as "Polyphenol." | en_US |
dc.description.abstract | Purpose: Neuroblastoma is a rare childhood cancer whose high risk, metastatic form has a dismal outcome in spite of aggressive therapeutic interventions. The toxicity of drug treatments is a major problem in this pediatric setting. In this study, we investigated whether Polyphenon E, a clinical grade mixture of green tea catechins under evaluation in multiple clinical cancer trials run by the National Cancer Institute (Bethesda, MD), has anticancer activity in mouse models of neuroblastoma. Experimental Design: We used three neuroblastoma models: (i) transgenic TH-MYCN mouse developing spontaneous neuroblastomas; (ii) nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice xenotransplanted with human SHSY5Y cells; and (iii) A/J mice transplanted with syngeneic Neuro 2A cells. Mice were randomized in control and Polyphenon E–drinking groups. Blood from patients with neuroblastoma and normal controls was used to assess the phenotype and function of myeloid cells. Results: Polyphenon E reduced the number of tumor-infiltrating myeloid cells, and inhibited the development of spontaneous neuroblastomas in TH-MYCN transgenic mice. In therapeutic models of neuroblastoma in A/J, but not in immunodeficient NOD/SCID mice, Polyphenon E inhibited tumor growth by acting on myeloid-derived suppressor cells (MDSC) and CD8 T cells. In vitro, Polyphenon E impaired the development and motility of MDSCs and promoted differentiation to more neutrophilic forms through the 67 kDa laminin receptor signaling and induction of granulocyte colony-stimulating factor. The proliferation of T cells infiltrating a patient metastasis was reactivated by Polyphenon E. Conclusions: These findings suggest that the neuroblastoma-promoting activity of MDSCs can be manipulated pharmacologically in vivo and that green tea catechins operate, at least in part, through this mechanism. | en_US |
dc.description.sponsorship | SPARKS, Research in Childhood Cancer, the CGD Research Trust, and the Wellcome Trust. | en_US |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | American Association of Cancer Research | en_US |
dc.subject | Catechins | en_US |
dc.subject | G-CSF | en_US |
dc.subject | Lymphocytes | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Neuroblastoma | en_US |
dc.title | Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1158/1078-0432.CCR-12-2528 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff TxP | - |
pubs.organisational-data | /Brunel/Brunel Active Staff TxP/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Active Staff TxP/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 479.86 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.