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http://bura.brunel.ac.uk/handle/2438/8935
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DC Field | Value | Language |
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dc.contributor.author | Vagnarelli, P | - |
dc.contributor.author | Ribeiro, S | - |
dc.contributor.author | Sennels, L | - |
dc.contributor.author | Sanchez-Pulido, L | - |
dc.contributor.author | de Lima Alves, F | - |
dc.contributor.author | Verheyen, T | - |
dc.contributor.author | Kelly, DA | - |
dc.contributor.author | Ponting, CP | - |
dc.contributor.author | Rappsilber, J | - |
dc.contributor.author | Earnshaw, WC | - |
dc.date.accessioned | 2014-08-19T15:57:30Z | - |
dc.date.available | 2014-08-19T15:57:30Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Developmental Cell, 21(2), 328 - 342, 2011 | en_US |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1534580711002541 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8935 | - |
dc.description | This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 Elsevier Inc. | en_US |
dc.description.abstract | Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man:PP1 complex forms in anaphase following dephosphorylation of Repo-Man. Upon activation, the complex localizes to chromosomes and causes the dephosphorylation of histone H3 (Thr3, Ser10, and Ser28). In anaphase, Repo-Man has both catalytic and structural functions that are mediated by two separate domains. A C-terminal domain localizes Repo-Man to bulk chromatin in early anaphase. There, it targets PP1 for the dephosphorylation of histone H3 and possibly other chromosomal substrates. An N-terminal domain localizes Repo-Man to the chromosome periphery later in anaphase. There, it is responsible for the recruitment of nuclear components such as Importin β and Nup153 in a PP1-independent manner. These observations identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit. | en_US |
dc.description.sponsorship | The Wellcome Trust, the Medical Research Council, and the European Commission. | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Repo-Man | en_US |
dc.subject | Mitotic exit | en_US |
dc.subject | Chromosomal reorganization | en_US |
dc.subject | Nuclear envelope reassembly | en_US |
dc.title | Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.devcel.2011.06.020 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
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Fulltext.pdf | 2.84 MB | Adobe PDF | View/Open |
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