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DC Field | Value | Language |
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dc.contributor.author | Romer, LM | - |
dc.contributor.author | Haverkamp, HC | - |
dc.contributor.author | Amann, M | - |
dc.contributor.author | Lovering, AT | - |
dc.contributor.author | Pegelow, DF | - |
dc.contributor.author | Dempsey, JA | - |
dc.date.accessioned | 2015-01-22T14:22:18Z | - |
dc.date.available | 2007 | - |
dc.date.available | 2015-01-22T14:22:18Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292:1, pp. R598 - R606, 2007 | en_US |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.uri | http://ajpregu.physiology.org/content/292/1/R598 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/9911 | - |
dc.description.abstract | Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292: R598–R606, 2007. First published September 7, 2006; doi:10.1152/ajpregu.00269.2006.—We hypothesized that severe hypoxia limits exercise performance via decreased contractility of limb locomotor muscles. Nine male subjects [mean SE maximum O2 uptake (V˙ O2 max) 56.5 2.7 ml kg 1 min 1] cycled at 90% V˙ O2 max to exhaustion in normoxia [NORM-EXH; inspired O2 fraction (FIO2) 0.21, arterial O2 saturation (SpO2) 93 1%] and hypoxia (HYPOX-EXH; FIO2 0.13, SpO2 76 1%). The subjects also exercised in normoxia for a time equal to that achieved in hypoxia (NORM-CTRL; SpO2 96 1%). Quadriceps twitch force, in response to supramaximal single (nonpotentiated and potentiated 1 Hz) and paired magnetic stimuli of the femoral nerve (10–100 Hz), was assessed pre- and at 2.5, 35, and 70 min postexercise. Hypoxia exacerbated exercise-induced peripheral fatigue, as evidenced by a greater decrease in potentiated twitch force in HYPOX-EXH vs. NORM-CTRL ( 39 4 vs. 24 3%, P 0.01). Time to exhaustion was reduced by more than two-thirds in HYPOX-EXH vs. NORM-EXH (4.2 0.5 vs. 13.4 0.8 min, P 0.01); however, peripheral fatigue was not different in HYPOX-EXH vs. NORM-EXH ( 34 4 vs. 39 4%, P 0.05). Blood lactate concentration and perceptions of limb discomfort were higher throughout HYPOX-EXH vs. NORM-CTRL but were not different at end-exercise in HYPOX-EXH vs. NORM-EXH. We conclude that severe hypoxia exacerbates peripheral fatigue of limb locomotor muscles and that this effect may contribute, in part, to the early termination of exercise. | en_US |
dc.format.extent | R598 - R606 | - |
dc.format.extent | R598 - R606 | - |
dc.language.iso | en | en_US |
dc.relation.isreplacedby | 2438/10071 | - |
dc.relation.isreplacedby | http://bura.brunel.ac.uk/handle/2438/10071 | - |
dc.subject | Hypoxemia | en_US |
dc.subject | Muscle fatigue | en_US |
dc.subject | Exercise performance | en_US |
dc.title | Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1152/ajpregu.00269.2006 | - |
dc.relation.isPartOf | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | - |
dc.relation.isPartOf | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | - |
pubs.issue | 1 | - |
pubs.issue | 1 | - |
pubs.volume | 292 | - |
pubs.volume | 292 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Sport Dept of Life Sciences Research Papers |
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