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http://bura.brunel.ac.uk/handle/2438/9913
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DC Field | Value | Language |
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dc.contributor.author | Bailey, SJ | - |
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Jelly, J | - |
dc.contributor.author | Wilkerson, DP | - |
dc.contributor.author | DiMenna, FJ | - |
dc.contributor.author | Jones, AM | - |
dc.date.accessioned | 2015-01-22T14:49:21Z | - |
dc.date.available | 2010-05-27 | - |
dc.date.available | 2015-01-22T14:49:21Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Applied Physiology, 109:2, pp. 457 - 468, 2010 | en_US |
dc.identifier.issn | 8750-7587 | - |
dc.identifier.uri | http://jap.physiology.org/content/109/2/457 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/9913 | - |
dc.description.abstract | Fatigue of the respiratory muscles during intense exercise might compromise leg blood flow, thereby constraining oxygen uptake (VO2) and limiting exercise tolerance. We tested the hypothesis that inspiratory muscle training (IMT) would reduce inspiratory muscle fatigue, speed VO2 kinetics and enhance exercise tolerance. Sixteen recreationally active subjects (mean ± SD, age 22 ± 4 yr) were randomly assigned to receive 4 wk of either pressure threshold IMT [30 breaths twice daily at ~50% of maximum inspiratory pressure (MIP)] or sham treatment (60 breaths once daily at ~15% of MIP). The subjects completed moderate-, severe- and maximal-intensity "step" exercise transitions on a cycle ergometer before (Pre) and after (Post) the 4-wk intervention period for determination of VO2 kinetics and exercise tolerance. There were no significant changes in the physiological variables of interest after Sham. After IMT, baseline MIP was significantly increased (Pre vs. Post: 155 ± 22 vs. 181 ± 21 cmH2O; P < 0.001), and the degree of inspiratory muscle fatigue was reduced after severe- and maximal-intensity exercise. During severe exercise, the VO2 slow component was reduced (Pre vs. Post: 0.60 ± 0.20 vs. 0.53 ± 0.24 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 765 ± 249 vs. 1,061 ± 304 s; P < 0.01). Similarly, during maximal exercise, the VO2 slow component was reduced (Pre vs. Post: 0.28 ± 0.14 vs. 0.18 ± 0.07 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 177 ± 24 vs. 208 ± 37 s; P < 0.01). Four weeks of IMT, which reduced inspiratory muscle fatigue, resulted in a reduced VO2 slow-component amplitude and an improved exercise tolerance during severe- and maximal-intensity exercise. The results indicate that the enhanced exercise tolerance observed after IMT might be related, at least in part, to improved VO2 dynamics, presumably as a consequence of increased blood flow to the exercising limbs. | en_US |
dc.format.extent | 457 - 468 | - |
dc.format.extent | 457 - 468 | - |
dc.language.iso | en | en_US |
dc.publisher | American Physiological Society | en_US |
dc.relation.isreplacedby | 2438/10116 | - |
dc.relation.isreplacedby | http://bura.brunel.ac.uk/handle/2438/10116 | - |
dc.subject | Fatigue | en_US |
dc.subject | Respiratory muscles | en_US |
dc.subject | Intense exercise | en_US |
dc.title | Inspiratory muscle training enhances pulmonary O2 uptake kinetics and high-intensity exercise tolerance in humans | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1152/japplphysiol.00077.2010 | - |
dc.relation.isPartOf | Journal of Applied Physiology | - |
dc.relation.isPartOf | Journal of Applied Physiology | - |
pubs.issue | 2 | - |
pubs.issue | 2 | - |
pubs.volume | 109 | - |
pubs.volume | 109 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Sport Dept of Life Sciences Research Papers |
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