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http://bura.brunel.ac.uk/handle/2438/9916
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DC Field | Value | Language |
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dc.contributor.author | Lovering, AT | - |
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Haverkamp, HC | - |
dc.contributor.author | Hokanson, JS | - |
dc.contributor.author | Eldridge, MW | - |
dc.coverage.spatial | United States | - |
dc.coverage.spatial | United States | - |
dc.date.accessioned | 2015-01-23T11:58:47Z | - |
dc.date.available | 2007 | - |
dc.date.available | 2015-01-23T11:58:47Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | High Altitude Medicine and Biology, 8:1, pp. 62 - 67, 2007 | en_US |
dc.identifier.issn | 1527-0297 | - |
dc.identifier.uri | http://online.liebertpub.com/doi/abs/10.1089/ham.2006.0816 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/9916 | - |
dc.description.abstract | A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness. | en_US |
dc.format.extent | 62 - 67 | - |
dc.format.extent | 62 - 67 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.subject | Adult | en_US |
dc.subject | Altitude Sickness | en_US |
dc.subject | Bronchopulmonary Dysplasia | en_US |
dc.subject | Exercise | en_US |
dc.subject | Exercise Test | en_US |
dc.subject | Exercise Tolerance | en_US |
dc.subject | Forced Expiratory Flow Rates | en_US |
dc.subject | Forced Expiratory Volume | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant, Newborn | en_US |
dc.subject | Male | en_US |
dc.subject | Oxygen Consumption | en_US |
dc.subject | Pulmonary Edema | en_US |
dc.subject | Pulmonary Gas Exchange | en_US |
dc.title | Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1089/ham.2006.0816 | - |
dc.relation.isPartOf | High Altitude Medicine and Biology | - |
dc.relation.isPartOf | High Altitude Medicine and Biology | - |
pubs.issue | 1 | - |
pubs.issue | 1 | - |
pubs.volume | 8 | - |
pubs.volume | 8 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Sport Dept of Life Sciences Research Papers |
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Fulltext.pdf | 204.41 kB | Adobe PDF | View/Open |
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