Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/10839
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DC Field | Value | Language |
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dc.contributor.author | Ferluga, J | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Sim, RB | - |
dc.date.accessioned | 2015-05-13T11:16:15Z | - |
dc.date.available | 2014 | - |
dc.date.available | 2015-05-13T11:16:15Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Molecular Immunology, 59(2):188 - 193, (March 2014) | en_US |
dc.identifier.issn | 0161-5890 | - |
dc.identifier.issn | 1872-9142 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0161589014000406 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/10839 | - |
dc.description.abstract | Anti-phospholipid syndrome (APS) is a complex autoimmune disease, associated with recurrent venous and arterial thrombosis in various tissues. APS is associated with specific antibodies against plasma beta-2 glycoprotein 1 (β2-GP1), and these antibodies react with β2-GP1 bound to negatively charged phospholipids (e.g. cardiolipin) on cell membranes. Some APS patients also have autoantibodies to complement factor H (FH), a homologue of β2-GP1, which also binds to anionic phospholipids. β2-GP1 has earlier been shown to inhibit the intrinsic (contact) activated blood coagulation pathway, promoted by anionic phospholipids. Here we examine whether FH could have similar anti-thrombotic properties. In vitro experiments with surface-bound phospholipids and human plasma, in the presence of FH, confirm this hitherto unreported property of FH. | en_US |
dc.format.extent | 188 - 193 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.subject | Anti-phospholipid syndrome | en_US |
dc.subject | Coagulation | en_US |
dc.subject | Complement | en_US |
dc.subject | Factor H | en_US |
dc.title | A potential anti-coagulant role of complement factor H | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.molimm.2014.02.012 | - |
dc.relation.isPartOf | Molecular Immunology | - |
pubs.issue | 2 | - |
pubs.issue | 2 | - |
pubs.issue | 2 | - |
pubs.issue | 2 | - |
pubs.volume | 59 | - |
pubs.volume | 59 | - |
pubs.volume | 59 | - |
pubs.volume | 59 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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Fulltext.doc | 375 kB | Microsoft Word | View/Open |
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