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http://bura.brunel.ac.uk/handle/2438/11683
Title: | Natural AD-like neuropathology in Octodon degus: Impaired burrowing and neuroinflammation |
Authors: | Deacon, RMJ Altimiras, FJ Bazán-León, EA Pyarasani, RD Nachtigall, FM Santos, LS Tsolaki, AG Pednekar, L Kishore, U Biekofsky, RR Vásquez, RA Cogram, P |
Keywords: | Alzheimer’s disease;Beta-amyloid;Burrowing;Complement;Cytokines;Octodon degus |
Issue Date: | 2015 |
Publisher: | Bentham Science |
Citation: | Current Alzheimer Research,12 (4): pp. 314 - 322, (2015) |
Abstract: | Alzheimer’s disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs of AD, including amyloid-β (Aβ) and tau deposits, as well as a decline in cognition with age. Firstly, the present work introduces a novel behavioral assessment for O. degus - the burrowing test - which appears to be a useful tool for detecting neurodegeneration in the O. degus model for AD. Such characterization has potentially wide-ranging implications, because many of these changes in species-typical behaviors are reminiscent of the impairments in activities of daily living (ADL), so characteristic of human AD. Furthermore, the present work characterizes the ADlike neuropathology in O. degus from a gene expression point of view, revealing a number of previously unreported AD biomarkers, which are found in human AD: amyloid precursor protein (APP), apolipoprotein E (ApoE), oxidative stressrelated genes from the NFE2L2 and PPAR pathway, as well as pro-inflammatory cytokines and complement proteins, in agreement with the known link between neurodegeneration and neuroinflammation. In summary, the present results confirm a natural neuropathology in O. degus with similar characteristics to AD at behavioral, cellular and molecular levels. These characteristics put O. degus in a singular position as a natural rodent model for research into AD pathogenesis and therapeutics against AD. |
URI: | http://www.eurekaselect.com/129747/article http://bura.brunel.ac.uk/handle/2438/11683 |
DOI: | http://dx.doi.org/10.2174/1567205012666150324181652 |
ISSN: | 1567-2050 1875-5828 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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