Title: | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism |
Authors: | Horikoshi, M Yaghootkar, H Mook-Kanamori, DO Sovio, U Taal, HR Hennig, BJ Bradfield, JP St Pourcain, B Evans, DM Charoen, P Kaakinen, M Tiesler, CMT Toenjes, A Prentice, AM Vaag, A Viikari, JS Vink, JM Vissing, NH Wareham, NJ Willemsen, G Witte, DR Lawlor, DA Zhang, H Meyer, BF Pearson, ER Boreham, CAG Cooper, C Gillman, MW Dedoussis, GV Cousminer, DL Moreno, LA Pedersen, O Smith, GD Saarinen, M Mohlke, KL Boomsma, DI Saw, S-M Lakka, TA Koerner, A Loos, RJF Ong, KK Lehtimaki, T Vollenweider, P Warrington, NM van Duijn, CM Koppelman, GH Hattersley, AT Holloway, JW Hocher, B Heinrich, J Power, C Melbye, M Guxens, M Kreiner-Moller, E Frayling, TM Pennell, CE Bonnelykke, K Bisgaard, H Eriksson, JG Widen, E Hakonarson, H Uitterlinden, AG Pouta, A McCarthy, MI Grant, SFA Jaddoe, VWV Jarvelin, M-R Timpson, NJ Prokopenko, I Dallongeville, J Freathy, RM Bustamante, M Feenstra, B Berry, DJ Thiering, E Pfab, T Barton, SJ Shields, BM Kerkhof, M van Leeuwen, EM Das, S Fulford, AJ Kutalik, Z Zhao, JH den Hoed, M Mahajan, A Lindi, V Goh, L-K Hottenga, J-J Wu, Y Raitakari, OT de Geus, EJC Harder, MN Meirhaeghe, A Ntalla, I Salem, RM Jameson, KA Zhou, K Monies, DM Lagou, V Kirin, M Heikkinen, J Estivill, X Adair, LS Alkuraya, FS Al-Odaib, A Amouyel, P Andersson, EA Bennett, AJ Blakemore, AIF Buxton, JL Flexeder, C Froguel, P Geller, F Godfrey, KM Gottrand, F Groves, CJ Zhao, J Hansen, T Hirschhorn, JN Hofman, A Hollegaard, MV Hougaard, DM Hyppoenen, E Inskip, HM Isaacs, A Jorgensen, T Kanaka-Gantenbein, C Wilson, JF Kemp, JP Kiess, W Kilpelainen, TO Klopp, N Knight, BA Kuzawa, CW McMahon, G Newnham, JP Niinikoski, H Oostra, BA Stumvoll, M Pedersen, L Postma, DS Ring, SM Rivadeneira, F Robertson, NR Sebert, S Simell, O Slowinski, T |
Keywords: | genetics & heredity;blood-pressure;fasting glucose;head circumference;glucokinase gene;metaanalysis;genome-wide association studies |
Issue Date: | 2013 |
Publisher: | Nature Publishing Group |
Citation: | Horikoshi, M. et al. (2013) 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', Nature Genetics, 45(1): pp. 76 - 82. doi: 10.1038/ng.2477. |
Abstract: | Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. |
URI: | https://bura.brunel.ac.uk/handle/2438/14638 |
DOI: | https://doi.org/10.1038/ng.2477 |
ISSN: | 1061-4036 |
Appears in Collections: | Dept of Life Sciences Research Papers
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