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Title: A genome-wide association meta-analysis identifies new childhood obesity loci
Authors: Bradfield, JP
Taal, HR
Timpson, NJ
Scherag, A
Lecoeur, C
Warrington, NM
Hypponen, E
Holst, C
Valcarcel, B
Thiering, E
Salem, RM
Schumacher, FR
Cousminer, DL
Sleiman, PMA
Zhao, J
Berkowitz, RI
Vimaleswaran, KS
Jarick, I
Pennell, CE
Evans, DM
St Pourcain, B
Berry, DJ
Mook-Kanamori, DO
Hofman, A
Rivadeneira, F
Uitterlinden, AG
van Duijn, CM
van der Valk, RJP
de Jongste, JC
Postma, DS
Boomsma, DI
Gauderman, WJ
Hassanein, MT
Lindgren, CM
Magi, R
Boreham, CAG
Neville, CE
Moreno, LA
Elliott, P
Pouta, A
Hartikainen, A-L
Li, M
Raitakari, O
Lehtimaki, T
Eriksson, JG
Palotie, A
Dallongeville, J
Das, S
Deloukas, P
McMahon, G
Ring, SM
Kemp, JP
Buxton, JL
Blakemore, AIF
Bustamante, M
Guxens, M
Hirschhorn, JN
Gillman, MW
Kreiner-Moller, E
Bisgaard, H
Gilliland, FD
Heinrich, J
Wheeler, E
Barroso, I
O'Rahilly, S
Meirhaeghe, A
Sorensen, TIA
Power, C
Palmer, LJ
Hinney, A
Widen, E
Farooqi, IS
McCarthy, MI
Froguel, P
Meyre, D
Hebebrand, J
Jarvelin, M-R
Jaddoe, VWV
Smith, GD
Hakonarson, H
Grant, SFA
Keywords: Body-mass index;Helicobacter-pylori;Disease genetics;Genome-wide association studies;Obesity
Issue Date: 2012
Publisher: Nature Publishing Group
Citation: Nature Genetics, 44(5): pp. 526 - 531, (2012)
Abstract: Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1.
ISSN: 1061-4036
Appears in Collections:Dept of Life Sciences Research Papers

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