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http://bura.brunel.ac.uk/handle/2438/14649
Title: | A genome-wide association meta-analysis identifies new childhood obesity loci |
Authors: | Bradfield, JP Taal, HR Timpson, NJ Scherag, A Lecoeur, C Warrington, NM Hypponen, E Holst, C Valcarcel, B Thiering, E Salem, RM Schumacher, FR Cousminer, DL Sleiman, PMA Zhao, J Berkowitz, RI Vimaleswaran, KS Jarick, I Pennell, CE Evans, DM St Pourcain, B Berry, DJ Mook-Kanamori, DO Hofman, A Rivadeneira, F Uitterlinden, AG van Duijn, CM van der Valk, RJP de Jongste, JC Postma, DS Boomsma, DI Gauderman, WJ Hassanein, MT Lindgren, CM Magi, R Boreham, CAG Neville, CE Moreno, LA Elliott, P Pouta, A Hartikainen, A-L Li, M Raitakari, O Lehtimaki, T Eriksson, JG Palotie, A Dallongeville, J Das, S Deloukas, P McMahon, G Ring, SM Kemp, JP Buxton, JL Blakemore, AIF Bustamante, M Guxens, M Hirschhorn, JN Gillman, MW Kreiner-Moller, E Bisgaard, H Gilliland, FD Heinrich, J Wheeler, E Barroso, I O'Rahilly, S Meirhaeghe, A Sorensen, TIA Power, C Palmer, LJ Hinney, A Widen, E Farooqi, IS McCarthy, MI Froguel, P Meyre, D Hebebrand, J Jarvelin, M-R Jaddoe, VWV Smith, GD Hakonarson, H Grant, SFA |
Keywords: | Body-mass index;Helicobacter-pylori;Disease genetics;Genome-wide association studies;Obesity |
Issue Date: | 2012 |
Publisher: | Nature Publishing Group |
Citation: | Nature Genetics, 44(5): pp. 526 - 531, (2012) |
Abstract: | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1. |
URI: | http://bura.brunel.ac.uk/handle/2438/14649 |
DOI: | http://dx.doi.org/10.1038/ng.2247 |
ISSN: | 1061-4036 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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