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Title: Development of a Scalable and Sustainable High Performance CounterCurrent Chromatography (HPCCC) Purification for Spinosyn A and Spinosyn D from Spinosad
Authors: Yang, Q
Bright, C
Edwards, NA
Harris, GH
Kaur, S
Wood, PL
Hewitson, P
Ignatova, S
Issue Date: 2017
Citation: Organic Process Research and Development, 2017, 21 (10), pp. 1638 - 1643
Abstract: © 2017 American Chemical Society. A high-performance countercurrent chromatography (HPCCC) process was developed as a more efficient and sustainable alternative to reverse phase high-performance liquid chromatography (RP-HPLC) for the pilot-scale purification of the naturally occurring fermentation-derived insecticides, spinosyn A and spinosyn D, the major components of spinosad insecticide. While on pilot scale HPCCC and RP-HPLC both gave > 99% purities and comparable combined recoveries of 77% and 83%, respectively, HPCCC was much more efficient and sustainable by producing a 60% higher productivity, 11 times higher solute loading, 96% savings in stationary phase costs, and 42% reduction in solvent usage. The increase in productivity and reduction in solvent usage further reduced waste recycle and disposal costs, thus presenting significantly less environmental impact compared to RP-HPLC separations. The use of mixing on demand for a solvent system at the preparative scale allowed a complete automation with minimized solvent consumption.
ISSN: 1083-6160
Appears in Collections:Dept of Mechanical and Aerospace Engineering Embargoed Research Papers

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