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Title: Mechanisms and Biomarkers of Exercise-Induced Bronchoconstriction.
Authors: Kippelen, P
Anderson, SD
Hallstrand, TS
Keywords: Eicosanoids;Eosinophils;Epithelium;Hyperpnea;Mast cells;Osmolarity;Sensory nerves;Water loss
Issue Date: 2018
Citation: Immunol Allergy Clin North Am, 2018, 38 (2), pp. 165 - 182
Abstract: Exercise is a common trigger of bronchoconstriction. In recent years, there has been increased understanding of the pathophysiology of exercise-induced bronchoconstriction. Although evaporative water loss and thermal changes have been recognized stimuli for exercise-induced bronchoconstriction, accumulating evidence points toward a pivotal role for the airway epithelium in orchestrating the inflammatory response linked to exercise-induced bronchoconstriction. Overproduction of inflammatory mediators, underproduction of protective lipid mediators, and infiltration of the airways with eosinophils and mast cells are all established contributors to exercise-induced bronchoconstriction. Sensory nerve activation and release of neuropeptides maybe important in exercise-induced bronchoconstriction, but further research is warranted.
Appears in Collections:Dept of Life Sciences Research Papers

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