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http://bura.brunel.ac.uk/handle/2438/16148
Title: | Mechanisms and Biomarkers of Exercise-Induced Bronchoconstriction. |
Authors: | Kippelen, P Anderson, SD Hallstrand, TS |
Keywords: | Eicosanoids;Eosinophils;Epithelium;Hyperpnea;Mast cells;Osmolarity;Sensory nerves;Water loss |
Issue Date: | 2018 |
Citation: | Immunol Allergy Clin North Am, 2018, 38 (2), pp. 165 - 182 |
Abstract: | Exercise is a common trigger of bronchoconstriction. In recent years, there has been increased understanding of the pathophysiology of exercise-induced bronchoconstriction. Although evaporative water loss and thermal changes have been recognized stimuli for exercise-induced bronchoconstriction, accumulating evidence points toward a pivotal role for the airway epithelium in orchestrating the inflammatory response linked to exercise-induced bronchoconstriction. Overproduction of inflammatory mediators, underproduction of protective lipid mediators, and infiltration of the airways with eosinophils and mast cells are all established contributors to exercise-induced bronchoconstriction. Sensory nerve activation and release of neuropeptides maybe important in exercise-induced bronchoconstriction, but further research is warranted. |
URI: | http://bura.brunel.ac.uk/handle/2438/16148 |
DOI: | http://dx.doi.org/10.1016/j.iac.2018.01.008 |
ISSN: | https://www.ncbi.nlm.nih.gov/pubmed/29631728 S0889-8561(18)30008-0 https://www.ncbi.nlm.nih.gov/pubmed/29631728 S0889-8561(18)30008-0 1557-8607 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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