Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/17063
Title: Combining trait and state model systems of psychosis: The effect of sleep deprivation on cognitive functions in schizotypal individuals
Authors: Kumari, V
Faiola, E
Meyhöfer, I
Kasparbauer, A-M
Ettinger, U
Keywords: Schizophrenia spectrum;Schizotypal personality traits;Cognitive biomarkers
Issue Date: 2018
Publisher: Elsevier
Citation: Psychiatry Research
Abstract: Model systems of psychosis play an important role in pathophysiology and drug development research. Schizotypal individuals display similar cognitive impairments as schizophrenia patients in several domains. Therefore, schizotypy may be interpreted as a trait model system of psychosis. In addition, experimentally controlled sleep deprivation is aputative state psychosis model that evokes subclinical psychosis-like states.We aimed to further validate these model systems by examining them in relation to central cognitive biomarkers of schizophrenia. Most of all, we were interested in investigating, for the first time, effects of their combination on cognitive function. Healthy subjects with high (N=17) or low (N=19) levels of schizotypy performed a cognitive task battery after one night of normal sleep and after 24h of sleep deprivation. Sleep deprivation impaired performance in the go /nogo and n-back tasks relative to the normal sleep control condition. No differences between groups orinteractions of group with sleep condition were found.The role of sleep deprivation as a model of psychosis is thus supported to some extent by impairments in inhibitory control. However, classical measures of cognition may be less able to detect deficits in schizotypy, in line with evidence of more basic information processing dysfunctions in schizotypy.
URI: http://bura.brunel.ac.uk/handle/2438/17063
ISSN: 1872-7123
Appears in Collections:Dept of Life Sciences Embargoed Research Papers

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