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DC Field | Value | Language |
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dc.contributor.author | Macare, C | - |
dc.contributor.author | Ducci, F | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Ruggeri, B | - |
dc.contributor.author | Jia, T | - |
dc.contributor.author | Kaakinen, M | - |
dc.contributor.author | Kalsi, G | - |
dc.contributor.author | Charoen, P | - |
dc.contributor.author | Casoni, F | - |
dc.contributor.author | Peters, J | - |
dc.contributor.author | Bromberg, U | - |
dc.contributor.author | Hill, M | - |
dc.contributor.author | Buxton, J | - |
dc.contributor.author | Blakemore, A | - |
dc.contributor.author | Veijola, J | - |
dc.contributor.author | Büchel, C | - |
dc.contributor.author | Banaschewski, T | - |
dc.contributor.author | Bokde, ALW | - |
dc.contributor.author | Conrod, P | - |
dc.contributor.author | Flor, H | - |
dc.contributor.author | Frouin, V | - |
dc.contributor.author | Gallinat, J | - |
dc.contributor.author | Garavan, H | - |
dc.contributor.author | Gowland, PA | - |
dc.contributor.author | Heinz, A | - |
dc.contributor.author | Ittermann, B | - |
dc.contributor.author | Lathrop, M | - |
dc.contributor.author | Martinot, JL | - |
dc.contributor.author | Paus, T | - |
dc.contributor.author | Desrivières, S | - |
dc.contributor.author | Munafò, M | - |
dc.contributor.author | Järvelin, MR | - |
dc.contributor.author | Schumann, G | - |
dc.date.accessioned | 2019-05-24T16:49:51Z | - |
dc.date.available | 2018-08-11 | - |
dc.date.available | 2019-05-24T16:49:51Z | - |
dc.date.issued | 2018-08-11 | - |
dc.identifier.citation | European Neuropsychopharmacology, 2018 | en_US |
dc.identifier.issn | 0924-977X | - |
dc.identifier.issn | http://dx.doi.org/10.1016/j.euroneuro.2018.07.101 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18217 | - |
dc.description.abstract | The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10−4) and higher plasma cotinine levels (p = 7.0 × 10−5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking. | en_US |
dc.description.sponsorship | European Union-funded FP6 Integrated Project IMAGEN | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | fMRI | en_US |
dc.subject | Genetics | en_US |
dc.subject | IMAGEN-ALSPAC-NFBC | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Risk taking | en_US |
dc.subject | Smoking | en_US |
dc.title | A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.euroneuro.2018.07.101 | - |
dc.relation.isPartOf | European Neuropsychopharmacology | - |
pubs.publication-status | Accepted | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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