Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/18217
Title: | A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response |
Authors: | Macare, C Ducci, F Zhang, Y Ruggeri, B Jia, T Kaakinen, M Kalsi, G Charoen, P Casoni, F Peters, J Bromberg, U Hill, M Buxton, J Blakemore, A Veijola, J Büchel, C Banaschewski, T Bokde, ALW Conrod, P Flor, H Frouin, V Gallinat, J Garavan, H Gowland, PA Heinz, A Ittermann, B Lathrop, M Martinot, JL Paus, T Desrivières, S Munafò, M Järvelin, MR Schumann, G |
Keywords: | fMRI;Genetics;IMAGEN-ALSPAC-NFBC;Meta-analysis;Risk taking;Smoking |
Issue Date: | 11-Aug-2018 |
Publisher: | Elsevier |
Citation: | European Neuropsychopharmacology, 2018 |
Abstract: | The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10−4) and higher plasma cotinine levels (p = 7.0 × 10−5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking. |
URI: | http://bura.brunel.ac.uk/handle/2438/18217 |
DOI: | http://dx.doi.org/10.1016/j.euroneuro.2018.07.101 |
ISSN: | 0924-977X http://dx.doi.org/10.1016/j.euroneuro.2018.07.101 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 961.65 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.