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Title: | Physiological and Pathophysiological Consequences of a 25-Day Ultra-Endurance Exercise Challenge |
Authors: | Tiller, NB Chiesa, ST Roberts, JD Turner, LA Jones, S Romer, LM |
Keywords: | Science & Technology;Life Sciences & Biomedicine;Physiology;cardiovascular;nutrition;respiratory;ultra-endurance;ultra-marathon;RESPIRATORY MUSCLE FATIGUE;FLOW-MEDIATED DILATION;LUNG-FUNCTION;STANDARDIZATION;PREDICTION;SOCIETY;SPORTS;IMPACT;FOOD |
Issue Date: | 15-May-2019 |
Publisher: | FRONTIERS MEDIA SA |
Citation: | FRONTIERS IN PHYSIOLOGY, 2019, 10 pp. ? - ? (8) |
Abstract: | Background: This case-report characterized the respiratory, cardiovascular, and nutritional/gastrointestinal (GI) responses of a trained individual to a novel ultra-endurance exercise challenge. Case Presentation: A male athlete (age 45 years; V˙V˙O2max 54.0 mL⋅kg-1⋅min-1) summited 100 mountains on foot in 25 consecutive days (all elevations >600 m).Measures: Laboratory measures of pulmonary function (spirometry, whole-body plethysmography, and single-breath rebreathe), respiratory muscle function (maximum static mouth-pressures), and cardiovascular structure and function (echocardiography, electrocardiography, large vessel ultrasound, and flow-mediated dilatation) were made at baseline and 48 h post-challenge. Dietary intake (four-day food diary), self-reported GI symptoms and plasma endotoxin concentrations were assessed at baseline, pre/post mid-point, pre/post end-point, and 48 h post-challenge. Results: The challenge was completed in a total exercise time of 142 h (5.3 ± 2.8 h⋅d-1), with a distance of 1141 km (42.3 ± 43.9 km⋅d-1), and energy expenditure of 80460 kcal (2980 ± 1451 kcal⋅d-1). Relative to baseline, there were post-challenge decreases in pulmonary capacities and expiratory flows (≤34%), maximum expiratory mouth-pressure (19%), and maximum voluntary ventilation (29%). Heart rate variability deteriorated, manifesting as a 48% decrease in the root mean square of successive differences and a 70% increase in the low-frequency/high-frequency ratio. Pre- to post-challenge endotoxin concentrations were elevated by 60%, with a maximum increase of 130% after a given stage, congruent with an increased frequency and severity of GI symptoms.Conclusion: The challenge resulted in pulmonary and autonomic dysfunction, endotoxaemia, and GI distress. The findings extend our understanding of the limits of physiological function and may inform medical best-practice for personnel supporting ultra-endurance events. |
URI: | http://bura.brunel.ac.uk/handle/2438/18492 |
DOI: | http://dx.doi.org/10.3389/fphys.2019.00589 |
ISSN: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 ARTN 589 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 ARTN 589 1664-042X http://dx.doi.org/10.3389/fphys.2019.00589 |
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Appears in Collections: | Dept of Life Sciences Research Papers |
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