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DC Field | Value | Language |
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dc.contributor.author | Romero, MC | - |
dc.contributor.author | Davare, M | - |
dc.contributor.author | Armendariz, M | - |
dc.contributor.author | Janssen, P | - |
dc.date.accessioned | 2019-10-17T12:18:11Z | - |
dc.date.available | 2019-12-01 | - |
dc.date.available | 2019-10-17T12:18:11Z | - |
dc.date.issued | 2019-06-14 | - |
dc.identifier.citation | Romero, M.C., Davare, M., Armendariz, M. et al. Neural effects of transcranial magnetic stimulation at the single-cell level. Nat Commun 10, 2642 (2019). | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/19332 | - |
dc.description.abstract | Transcranial magnetic stimulation (TMS) can non-invasively modulate neural activity in humans. Despite three decades of research, the spatial extent of the cortical area activated by TMS is still controversial. Moreover, how TMS interacts with task-related activity during motor behavior is unknown. Here, we applied single-pulse TMS over macaque parietal cortex while recording single-unit activity at various distances from the center of stimulation during grasping. The spatial extent of TMS-induced activation is remarkably restricted, affecting the spiking activity of single neurons in an area of cortex measuring less than 2 mm in diameter. In task-related neurons, TMS evokes a transient excitation followed by reduced activity, paralleled by a significantly longer grasping time. Furthermore, TMS-induced activity and task-related activity do not summate in single neurons. These results furnish crucial experimental evidence for the neural effects of TMS at the single-cell level and uncover the neural underpinnings of behavioral effects of TMS. | en_US |
dc.description.sponsorship | Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Odysseus (G.0007.12, G.0C51.13N), and Program Financing (PFV10/008). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.title | Neural effects of transcranial magnetic stimulation at the single-cell level | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1038/s41467-019-10638-7 | - |
dc.relation.isPartOf | Nature Communications | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 10 | - |
dc.identifier.eissn | 2041-1723 | - |
Appears in Collections: | Dept of Health Sciences Research Papers |
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FullText.pdf | 1.22 MB | Adobe PDF | View/Open |
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