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http://bura.brunel.ac.uk/handle/2438/19332
Title: | Neural effects of transcranial magnetic stimulation at the single-cell level |
Authors: | Romero, MC Davare, M Armendariz, M Janssen, P |
Issue Date: | 14-Jun-2019 |
Publisher: | Springer Nature |
Citation: | Romero, M.C., Davare, M., Armendariz, M. et al. Neural effects of transcranial magnetic stimulation at the single-cell level. Nat Commun 10, 2642 (2019). |
Abstract: | Transcranial magnetic stimulation (TMS) can non-invasively modulate neural activity in humans. Despite three decades of research, the spatial extent of the cortical area activated by TMS is still controversial. Moreover, how TMS interacts with task-related activity during motor behavior is unknown. Here, we applied single-pulse TMS over macaque parietal cortex while recording single-unit activity at various distances from the center of stimulation during grasping. The spatial extent of TMS-induced activation is remarkably restricted, affecting the spiking activity of single neurons in an area of cortex measuring less than 2 mm in diameter. In task-related neurons, TMS evokes a transient excitation followed by reduced activity, paralleled by a significantly longer grasping time. Furthermore, TMS-induced activity and task-related activity do not summate in single neurons. These results furnish crucial experimental evidence for the neural effects of TMS at the single-cell level and uncover the neural underpinnings of behavioral effects of TMS. |
URI: | https://bura.brunel.ac.uk/handle/2438/19332 |
DOI: | https://doi.org/10.1038/s41467-019-10638-7 |
ISSN: | 2041-1723 |
Appears in Collections: | Dept of Health Sciences Research Papers |
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