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Title: The Nuclear Lamina: Protein Accumulation, Disease and Clearance
Authors: Almendáriz-Palacios, C
Gillespie, ZE
Janzen, M
Martinez, V
Bridger, JM
Harkness, TAA
Mousseau , DD
Eskiw, CH
Keywords: lamina;protein accumulation;premature aging;neurodegeneration;autophagy;clearance
Issue Date: 1-Jul-2020
Publisher: MDPI
Citation: Almendáriz-Palacios, C.; Gillespie, Z.E.; Janzen, M.; Martinez, V.; Bridger, J.M.; Harkness, T.A.A.; Mousseau, D.D.; Eskiw, C.H. The Nuclear Lamina: Protein Accumulation and Disease. Biomedicines 2020, 8, 188.
Abstract: © 2020 by the authors. Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging. One proteinaceous structure underlying the nuclear envelope—the nuclear lamina—coordinates essential processes including DNA repair, genome organization and epigenetic and transcriptional regulation. Loss of proteostasis within the nuclear lamina results in accumulation of proteins, disrupting these essential functions, either via direct interactions of protein aggregates with the lamina or by altering systems that maintain lamina structure. Here we discuss the links between proteostasis and disease of the nuclear lamina, as well as how manipulating specific proteostatic pathways involved in protein clearance could improve cellular health and prevent/reverse disease.
Description: This article belongs to the Special Issue Protein Structure, Function and Dynamics in Diseases and Therapeutics
ISSN: 2227-9059
Appears in Collections:Dept of Life Sciences Research Papers

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