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Title: | Is there a link between bisphenol A (BPA), a key endocrine disruptor, and the risk for SARS-CoV-2 infection and severe COVID-19? |
Authors: | Zahra, A Sisu, C Silva, E De Aguiar Greca, S-C Randeva, H Chatha, K Kyrou, I Karteris, E |
Keywords: | SARS-CoV-2;COVID-19;BPA;estrogen receptors;ACE2;TMPRSS2;endocrine disruptors |
Issue Date: | 14-Oct-2020 |
Publisher: | MDPI |
Citation: | Zahra, A., Sisu, C., Silva, E., De Aguiar Greca, S.-C., Randeva, H. S., Chatha, K., Kyrou, I. and Karteris, E. (2020) ‘Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?’, Journal of Clinical Medicine. MDPI AG, 9(10), 3296, pp. 1-15. doi: 10.3390/jcm9103296. |
Abstract: | © 2020 by the authors. Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals, so called, endocrine disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and, thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear estrogen receptors (ERα and ERβ), membrane-bound estrogen receptor GPR30 and human nuclear receptor estrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2), and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung, and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation. |
URI: | https://bura.brunel.ac.uk/handle/2438/21627 |
DOI: | https://doi.org/10.3390/jcm9103296 |
Other Identifiers: | 3296 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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