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dc.contributor.authorNg, N-
dc.contributor.authorWillems, SM-
dc.contributor.authorFernandez, J-
dc.contributor.authorFine, RS-
dc.contributor.authorWheeler, E-
dc.contributor.authorWessel, J-
dc.contributor.authorKitajima, H-
dc.contributor.authorMarenne, G-
dc.contributor.authorRundle, JK-
dc.contributor.authorSim, X-
dc.contributor.authorYeghootkar, H-
dc.contributor.authorVääräsmäki, M-
dc.contributor.authorVaartjes, I-
dc.contributor.authorEvans, MK-
dc.contributor.authorZoledziewska, M-
dc.contributor.authorChen, S-
dc.contributor.authorHansen, T-
dc.contributor.authorAbecasis, G-
dc.contributor.authorBalkau, B-
dc.contributor.authorScott, RA-
dc.contributor.authorFritsche, A-
dc.contributor.authorJustice, AE-
dc.contributor.authorBisgaard, H-
dc.contributor.authorHattersley, AT-
dc.contributor.authorElliott, P-
dc.contributor.authorde Haan, HG-
dc.contributor.authorHayward, C-
dc.contributor.authorHirschhorn, JN-
dc.contributor.authorBonnycastle, LL-
dc.contributor.authorGjesing, AP-
dc.contributor.authorIkram, MA-
dc.contributor.authorIngelsson, E-
dc.contributor.authorLo, KS-
dc.contributor.authorde Mutsert, R-
dc.contributor.authorKarpe, F-
dc.contributor.authorKaw, K-T-
dc.contributor.authorKiess, W-
dc.contributor.authorKooner, JS-
dc.contributor.authorKörner, A-
dc.contributor.authorConsortium, E-I-
dc.contributor.authorLakka, T-
dc.contributor.authorBots, ML-
dc.contributor.authorGrarup, N-
dc.contributor.authorHerzig, K-H-
dc.contributor.authorChasman, DI-
dc.contributor.authorBlakemore, AI-
dc.contributor.authorLangenberg, C-
dc.contributor.authorLind, L-
dc.contributor.authorLindgren, CM-
dc.contributor.authorLinneberg, A-
dc.contributor.authorLipovich, L-
dc.contributor.authorLiu, C-T-
dc.contributor.authorLiu, J-
dc.contributor.authorLiu, Y-
dc.contributor.authorMarouli, E-
dc.contributor.authorBrandslund, I-
dc.contributor.authorFarmaki, A-E-
dc.contributor.authorRotter, JI-
dc.contributor.authorLoos, RJF-
dc.contributor.authorBarroso, I-
dc.contributor.authorMacDonald, PE-
dc.contributor.authorLi-Gao, R-
dc.contributor.authorMohlke, KL-
dc.contributor.authorMorris, AD-
dc.contributor.authorMunroe, PB-
dc.contributor.authorMedina-Gomez, C-
dc.contributor.authorMurray, A-
dc.contributor.authorPadmanabhan, S-
dc.contributor.authorChen, J-
dc.contributor.authorArking, DE-
dc.contributor.authorPalmer, CNA-
dc.contributor.authorPasterkamp, G-
dc.contributor.authorFaul, JD-
dc.contributor.authorKleinbrink, EL-
dc.contributor.authorPedersen, O-
dc.contributor.authorPeyser, PA-
dc.contributor.authorJørgensen, ME-
dc.contributor.authorPolasek, O-
dc.contributor.authorVarga, TV-
dc.contributor.authorPorteous, D-
dc.contributor.authorProvince, MA-
dc.contributor.authorAuvinen, J-
dc.contributor.authorHivert, M-F-
dc.contributor.authorPsaty, BM-
dc.contributor.authorRauramaa, R-
dc.contributor.authorRidker, PM-
dc.contributor.authorRolandsson, O-
dc.contributor.authorAfaq, S-
dc.contributor.authorAhluwalia, TS-
dc.contributor.authorFranks, PW-
dc.contributor.authorRorsman, P-
dc.contributor.authorRosendaal, F-
dc.contributor.authorRudan, I-
dc.contributor.authorBielak, LF-
dc.contributor.authorSalomaa, V-
dc.contributor.authorChristensen, C-
dc.contributor.authorAsimit, JL-
dc.contributor.authorSchulze, MB-
dc.contributor.authorAlhejily, WA-
dc.contributor.authorSladek, R-
dc.contributor.authorSmith, BH-
dc.contributor.authorSpector, TD-
dc.contributor.authorAn, P-
dc.contributor.authorStarr, JM-
dc.contributor.authorFranks, S-
dc.contributor.authorBihlmeyer, NA-
dc.contributor.authorStumvoll, M-
dc.contributor.authorvan Duijn, CM-
dc.contributor.authorDanesh, J-
dc.contributor.authorDeary, IJ-
dc.contributor.authorWalker, M-
dc.contributor.authorBork-Jensen, J-
dc.contributor.authorCheng, C-Y-
dc.contributor.authorGoodarzi, MO-
dc.contributor.authorBrody, JA-
dc.contributor.authorCampbell, A-
dc.contributor.authorBlüher, M-
dc.contributor.authorDedoussis, G-
dc.contributor.authorChu, AY-
dc.contributor.authorDavies, G-
dc.contributor.authorChen, Y-
dc.contributor.authorDemirkan, A-
dc.contributor.authorFloyd, JS-
dc.contributor.authorGiulianini, F-
dc.contributor.authorGuo, X-
dc.contributor.authorGustafsson, S-
dc.contributor.authorClark, A-
dc.contributor.authorHastoy, B-
dc.contributor.authorBoeing, H-
dc.contributor.authorBeer, NL-
dc.contributor.authorMorris, AP-
dc.contributor.authorWareham, NJ-
dc.contributor.authorJackson, AU-
dc.contributor.authorJakobsdottir, J-
dc.contributor.authorJärvelin, M-R-
dc.contributor.authorJensen, RA-
dc.contributor.authorKanoni, S-
dc.contributor.authorKeinanen-Kiukaanniemi, S-
dc.contributor.authorLi, J-
dc.contributor.authorLi, M-
dc.contributor.authorBoerwinkle, E-
dc.contributor.authorCollins, FS-
dc.contributor.authorAmin, N-
dc.contributor.authorLohman, K-
dc.contributor.authorDehghan, A-
dc.contributor.authorLu, Y-
dc.contributor.authorGudnason, V-
dc.contributor.authorLuan, JA-
dc.contributor.authorManning, AK-
dc.contributor.authorMarten, J-
dc.contributor.authorMarzi, C-
dc.contributor.authorMeidtner, K-
dc.contributor.authorBønnelykke, K-
dc.contributor.authorJousilahti, P-
dc.contributor.authorMook-Kanamori, DO-
dc.contributor.authorMuka, T-
dc.contributor.authorCoresh, J-
dc.contributor.authorJansson, J-H-
dc.contributor.authorPistis, G-
dc.contributor.authorPrins, B-
dc.contributor.authorRice, KM-
dc.contributor.authorHallmans, G-
dc.contributor.authorRobertson, N-
dc.contributor.authorSanna, S-
dc.contributor.authorRaimondo, A-
dc.contributor.authorFerrannini, E-
dc.contributor.authorShi, Y-
dc.contributor.authorSmith, AV-
dc.contributor.authorSmith, JA-
dc.contributor.authorSoutham, L-
dc.contributor.authorJhun, MA-
dc.contributor.authorCucca, F-
dc.contributor.authorStringham, HM-
dc.contributor.authorTajuddin, SM-
dc.contributor.authorTragante, V-
dc.contributor.authorKajantie, E-
dc.contributor.authorvan der Laan, SW-
dc.contributor.authorBottinger, EP-
dc.contributor.authorHarris, TB-
dc.contributor.authorWarren, HR-
dc.contributor.authorYao, J-
dc.contributor.authorYiorkas, AM-
dc.contributor.authorZhang, W-
dc.contributor.authorBeck Jørgensen, T-
dc.contributor.authorZhao, W-
dc.contributor.authorde Borst, GJ-
dc.contributor.authorKaraleftheri, M-
dc.contributor.authorAhlqvist, E-
dc.contributor.authorGraff, M-
dc.contributor.authorCaulfield, MJ-
dc.contributor.authorHighland, HM-
dc.contributor.authorKardia, SLR-
dc.contributor.authorBoehnke, M-
dc.contributor.authorChen, Y-DI-
dc.contributor.authorKinnunen, L-
dc.contributor.authorKoistinena, HA-
dc.contributor.authorWeir, DR-
dc.contributor.authorGloyn, AL-
dc.contributor.authorKomulainen, P-
dc.contributor.authorKovacs, P-
dc.contributor.authorKuusisto, J-
dc.contributor.authorLaakso, M-
dc.contributor.authorLange, LA-
dc.contributor.authorTarasov, AI-
dc.contributor.authorLauner, LJ-
dc.contributor.authorFlorez, J-
dc.contributor.authorLee, J-J-
dc.contributor.authorFeng, S-
dc.contributor.authorEbeling, T-
dc.contributor.authorAsselbergs, FW-
dc.contributor.authorLeong, A-
dc.contributor.authorLindström, J-
dc.contributor.authorFox, JEM-
dc.contributor.authorMännistö, S-
dc.contributor.authorMaruthur, NM-
dc.contributor.authorMoilanen, L-
dc.contributor.authorMulas, A-
dc.contributor.authorNalls, MA-
dc.contributor.authorWilson, JG-
dc.contributor.authorMcCarthy, MI-
dc.contributor.authorThomsen, SK-
dc.contributor.authorChambers, JC-
dc.contributor.authorNeville, M-
dc.contributor.authorDeloukas, P-
dc.contributor.authorPankow, JS-
dc.contributor.authorPattie, A-
dc.contributor.authorPetersen, ERB-
dc.contributor.authorPuolijoki, H-
dc.contributor.authorRasheed, A-
dc.contributor.authorWong, TY-
dc.contributor.authorRedmond, P-
dc.contributor.authorRenström, F-
dc.contributor.authorMeigs, JB-
dc.contributor.authorFranco, OH-
dc.contributor.authorRoden, M-
dc.contributor.authorSaleheen, D-
dc.contributor.authorvan de Bunt, M-
dc.contributor.authorden Ruijter, HM-
dc.contributor.authorSaltevo, J-
dc.contributor.authorSavonen, K-
dc.contributor.authorAppel, EV-
dc.contributor.authorSébert, SP-
dc.contributor.authorSkaaby, T-
dc.contributor.authorSmall, KS-
dc.contributor.authorStančáková, A-
dc.contributor.authorGrallert, H-
dc.contributor.authorStrawbridge, RJ-
dc.contributor.authorStokholm, J-
dc.contributor.authorStrauch, K-
dc.contributor.authorTai, E-S-
dc.contributor.authorTaylor, KD-
dc.contributor.authorZeggini, E-
dc.contributor.authorDupuis, J-
dc.contributor.authorWang, S-
dc.contributor.authorThuesen, BH-
dc.contributor.authorTönjes, A-
dc.contributor.authorTsafantakis, E-
dc.contributor.authorGroop, L-
dc.contributor.authorTuomi, T-
dc.contributor.authorMahajan, A-
dc.contributor.authorTuomilehto, J-
dc.contributor.authorGroup, USS-
dc.contributor.authorZonderman, AB-
dc.contributor.authorUusitupa, MI-
dc.date.accessioned2020-10-25T07:37:43Z-
dc.date.available2019-10-15-
dc.date.available2020-10-25T07:37:43Z-
dc.date.issued2019-10-03-
dc.identifier.citationCell, [submitted version under consideration at Cell Press and has not been peer-reviewed.]en_US
dc.identifier.issn0092-8674-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/21693-
dc.identifier.urihttps://europepmc.org/article/ppr/ppr94720-
dc.identifier.urihttps://papers.ssrn.com/sol3/papers.cfm?abstract_id=3469835-
dc.descriptionbioRxiv preprint doi: https://doi.org/10.1101/790618; this version posted October 3, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license.en_US
dc.description.abstractMetabolic dysregulation in multiple tissues influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits we investigated associations of exome-array variants in up to 144,060 nondiabetic individuals of multiple ancestries. Single-variant analyses identified 21 novel coding variant associations (18 loci), whilst gene-based tests revealed novel signals at TF (HbA1c) and G6PC [(Fasting Glucose (FG), Fasting Insulin (FI)]. Pathway and tissue enrichment analyses of trait-associated transcripts confirmed the importance of liver and kidney for FI and islets for FG, implicated adipose tissue in FI and gut in 2hGlu, and a role for the non-endocrine pancreas in glucose homeostasis. Functional studies demonstrated that the liver-enriched G6PC and the islet-specific G6PC2 were driven by multiple rare variants, with G6PC2 including two alleles within the same codon with divergent effects on glucose levels. Our findings highlight the value of integrating genomic and functional data to maximize biological inference.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.subjectgeneticsen_US
dc.subjectGenomicsen_US
dc.subjectglycemic traitsen_US
dc.subjecttype 2 diabetesen_US
dc.subjecttissueen_US
dc.subjectpathwaysen_US
dc.subjecteffector transcripten_US
dc.titleTissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulationen_US
dc.typeArticleen_US
pubs.notesSource info: CELL-D-19-02838-
dc.identifier.eissn1097-4172-
Appears in Collections:Dept of Life Sciences Research Papers

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