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DC Field | Value | Language |
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dc.contributor.author | Agostinis, C | - |
dc.contributor.author | Mangogna, A | - |
dc.contributor.author | Balduit, A | - |
dc.contributor.author | Aghamajidi, A | - |
dc.contributor.author | Ricci, G | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Bulla, R | - |
dc.date.accessioned | 2021-12-18T19:02:54Z | - |
dc.date.available | 2021-12-18T19:02:54Z | - |
dc.date.issued | 2021-11-17 | - |
dc.identifier.citation | Agostinis, C., Mangogna, A., Balduit, A., Aghamajidi, A., Ricci, G., Kishore, U. and Bulla, R. (2021) 'COVID-19, Pre-Eclampsia, and Complement System', Frontiers in Immunology 12, 775168, pp. 1-20. doi: 10.3389/fimmu.2021.775168 | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23762 | - |
dc.description.abstract | Copyright © 2021 Agostinis, Mangogna, Balduit, Aghamajidi, Ricci, Kishore and Bulla. COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C) via its cross-talk with the contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infection during pregnancy are more vulnerable to developing PE. SARS-CoV-2 infection of ECs, via its receptor ACE2 and co-receptor TMPRSS2, can provoke endothelial dysfunction and disruption of vascular integrity, causing hyperinflammation and hypercoagulability. This is aggravated by bradykinin increase due to inhibition of ACE2 activity by the virus. C is important for the progression of normal pregnancy, and its dysregulation can impact in the form of PE-like syndrome as a consequence of SARS-CoV-2 infection. Thus, there is also an overlap between treatment regimens of COVID-19 and PE. C inhibitors, especially those targeting C3 or MASP-2, are exciting options for treating COVID-19 and consequent PE. In this review, we examine the role of C, contact and coagulation systems as well as endothelial hyperactivation with respect to SARS-CoV-2 infection during pregnancy and likely development of PE. | en_US |
dc.description.sponsorship | Ferring COVID-19 Investigational Grant (GRAVISAR to RB); Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy (RC24/19 to GR and 09/21 to CA). | en_US |
dc.format.extent | 1 - 20 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Frontiers SA | en_US |
dc.rights | Copyright © 2021 Agostinis, Mangogna, Balduit, Aghamajidi, Ricci, Kishore and Bulla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | COVID-19 | en_US |
dc.subject | complement system | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | pregnancy | en_US |
dc.subject | pre-eclampsia | en_US |
dc.title | COVID-19, Pre-Eclampsia, and Complement System | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2021.775168 | - |
dc.relation.isPartOf | Frontiers in Immunology | - |
pubs.publication-status | Published | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 1664-3224 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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