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http://bura.brunel.ac.uk/handle/2438/23762
Title: | COVID-19, Pre-Eclampsia, and Complement System |
Authors: | Agostinis, C Mangogna, A Balduit, A Aghamajidi, A Ricci, G Kishore, U Bulla, R |
Keywords: | COVID-19;complement system;SARS-CoV-2;pregnancy;pre-eclampsia |
Issue Date: | 17-Nov-2021 |
Publisher: | Frontiers SA |
Citation: | Agostinis, C., Mangogna, A., Balduit, A., Aghamajidi, A., Ricci, G., Kishore, U. and Bulla, R. (2021) 'COVID-19, Pre-Eclampsia, and Complement System', Frontiers in Immunology 12, 775168, pp. 1-20. doi: 10.3389/fimmu.2021.775168 |
Abstract: | Copyright © 2021 Agostinis, Mangogna, Balduit, Aghamajidi, Ricci, Kishore and Bulla. COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C) via its cross-talk with the contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infection during pregnancy are more vulnerable to developing PE. SARS-CoV-2 infection of ECs, via its receptor ACE2 and co-receptor TMPRSS2, can provoke endothelial dysfunction and disruption of vascular integrity, causing hyperinflammation and hypercoagulability. This is aggravated by bradykinin increase due to inhibition of ACE2 activity by the virus. C is important for the progression of normal pregnancy, and its dysregulation can impact in the form of PE-like syndrome as a consequence of SARS-CoV-2 infection. Thus, there is also an overlap between treatment regimens of COVID-19 and PE. C inhibitors, especially those targeting C3 or MASP-2, are exciting options for treating COVID-19 and consequent PE. In this review, we examine the role of C, contact and coagulation systems as well as endothelial hyperactivation with respect to SARS-CoV-2 infection during pregnancy and likely development of PE. |
URI: | https://bura.brunel.ac.uk/handle/2438/23762 |
DOI: | https://doi.org/10.3389/fimmu.2021.775168 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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