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DC Field | Value | Language |
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dc.contributor.author | Kamble, N | - |
dc.contributor.author | Gurung, A | - |
dc.contributor.author | Kaufer, BB | - |
dc.contributor.author | Pathan, AA | - |
dc.contributor.author | Behboudi, S | - |
dc.date.accessioned | 2022-01-22T17:01:10Z | - |
dc.date.available | 2022-01-22T17:01:10Z | - |
dc.date.issued | 2021-12-22 | - |
dc.identifier | 801781 | - |
dc.identifier.citation | Kamble, N., Gurung, A., Kaufer, B.B., Pathan, A.A. and Behboudi, S. (2021) 'Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2', Frontiers in Immunology, 12, 801781, pp. 1-16. doi: 10.3389/fimmu.2021.801781. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23983 | - |
dc.description.abstract | Copyright © 2021 Kamble, Gurung, Kaufer, Pathan and Behboudi. Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens. | en_US |
dc.description.sponsorship | U.K. Research and Innovation Biotechnology and Biological Sciences Research Council Grants BBS/E/I/00001825, BBS/E/I/00007030, BBS/E/I/00007031, BB/S01506X/1, BBS/E/I/00002529, BBS/E/I/00007039, BBS/E/I/00007032, BB/N002598/1 and BB/V019031/1. | en_US |
dc.format.extent | 1 - 16 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Frontiers Media S.A. | en_US |
dc.rights | Copyright © 2021 Kamble, Gurung, Kaufer, Pathan and Behboudi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Marek’s disease virus | en_US |
dc.subject | T cell proliferation | en_US |
dc.subject | cyclooxygenase 2 (COX2) | en_US |
dc.subject | PGE2 | en_US |
dc.subject | immunosuppression | en_US |
dc.title | Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2021.801781 | - |
dc.relation.isPartOf | Frontiers in Immunology | - |
pubs.publication-status | Published | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 1664-3224 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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