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Title: | Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2 |
Authors: | Kamble, N Gurung, A Kaufer, BB Pathan, AA Behboudi, S |
Keywords: | Marek’s disease virus;T cell proliferation;cyclooxygenase 2 (COX2);PGE2;immunosuppression |
Issue Date: | 22-Dec-2021 |
Publisher: | Frontiers Media S.A. |
Citation: | Kamble, N., Gurung, A., Kaufer, B.B., Pathan, A.A. and Behboudi, S. (2021) 'Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2', Frontiers in Immunology, 12, 801781, pp. 1-16. doi: 10.3389/fimmu.2021.801781. |
Abstract: | Copyright © 2021 Kamble, Gurung, Kaufer, Pathan and Behboudi. Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens. |
URI: | https://bura.brunel.ac.uk/handle/2438/23983 |
DOI: | https://doi.org/10.3389/fimmu.2021.801781 |
Other Identifiers: | 801781 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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