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http://bura.brunel.ac.uk/handle/2438/25335| Title: | Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer’s disease |
| Authors: | Manca, R Valera-Bermejo, JM Venneri, A |
| Keywords: | Alzheimer;delusions;dopamine;nigro-striatal;MRI;atrophy |
| Issue Date: | 13-May-2022 |
| Publisher: | Springer Nature |
| Citation: | Manca, R., Valera-Bermejo, J.M. and Venneri, A. for the Alzheimer’s Disease Neuroimaging Initiative (2022) 'Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer’s disease, European Archives of Psychiatry and Clinical Neuroscience, 273 (1), pp. 229 - 241. doi: 10.1007/s00406-022-01417-5. |
| Abstract: | Copyright © 2022 The Author(s). People with Alzheimer’s disease (AD) and delusions have worse quality of life and prognosis. However, early markers of delusions have not been identified yet. The present study investigated whether there are any detectable differences in grey matter (GM) volume and cognitive changes in the year before symptom onset between patients with AD who did and did not develop delusions. Two matched samples of AD patients, 63 who did (PT-D) and 63 who did not develop delusions (PT-ND) over 1 year, were identified from the Alzheimer’s Disease Neuroimaging Initiative database. The Neuropsychiatric Inventory (NPI) was used to assess the presence of delusions. Sixty-three additional matched healthy controls (HC) were selected. Repeated-measures ANCOVA models were used to investigate group-by-time effects on the volume of selected GM regions of interest and on cognitive performance. No neurocognitive differences were observed between patient groups prior to symptom onset. Greater episodic memory decline and GM loss in bilateral caudate nuclei, medio-temporal and midline cingulo-parietal regions were found in the PT-D compared with the PT-ND group. A pattern of faster GM loss in brain areas typically affected by AD and in cortical and subcortical targets of dopaminergic pathways, paralleled by worsening of episodic memory and behavioural symptoms, may explain the emergence of delusions in patients with AD. |
| Description: | Additional information: *Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf. Supplementary Information: Below is the link to the electronic supplementary material. Supplementary file1 available at https://static-content.springer.com/esm/art%3A10.1007%2Fs00406-022-01417-5/MediaObjects/406_2022_1417_MOESM1_ESM.docx (DOCX 21 KB). |
| URI: | https://bura.brunel.ac.uk/handle/2438/25335 |
| DOI: | https://doi.org/10.1007/s00406-022-01417-5 |
| ISSN: | 0940-1334 |
| Other Identifiers: | ORCID iDs: Riccardo Manca https://orcid.org/0000-0003-1715-6442; Annalena Venneri https://orcid.org/0000-0002-9488-2301. |
| Appears in Collections: | Dept of Life Sciences Research Papers |
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