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Title: Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia
Authors: Whiteside, DJ
Malpetti, M
Jones, PS
Ghosh, BCP
Coyle‐Gilchrist, I
van Swieten, JC
Seelaar, H
Jiskoot, L
Borroni, B
Sanchez‐Valle, R
Moreno, F
Verdelho, A
Freedman, M
Keren, R
Black, S
Mitchell, S
Shoesmith, C
Synofzik, M
Bartha, R
Balasa, M
Rademakers, R
Finger, E
Poos, J
Maruta, C
Papma, JM
Giannini, L
van Minkelen, R
Pijnenburg, Y
Ferrari, C
Polito, C
Brice, A
Lombardi, G
Colliot, O
Bessi, V
Bargalló, N
Ferreira, CB
Veldsman, M
Andersson, C
Thonberg, H
Öijerstedt, L
Jelic, V
Thompson, P
Langheinrich, T
Sayah, S
Miltenberger, G
Laforce, R
Simões do Couto, F
Gabilondo, A
Gorostidi, A
Zetterberg, H
Villanua, J
Funkiewiez, A
Cañada, M
Tainta, M
Prix, C
Zulaica, M
Barandiaran, M
Alves, P
Bender, B
Graff, C
Wilke, C
Tartaglia, MC
Graf, L
Vogels, A
Rinaldi, D
Wlasich, E
Vandenbulcke, M
Van Damme, P
Bruffaerts, R
Poesen, K
Rosa‐Neto, P
Gauthier, S
Camuzat, A
Wagemann, O
Todd, E
Loosli, S
Galimberti, D
Schönecker, S
Tang‐Wai, D
Hoegen, T
Vandenberghe, R
Lombardi, J
Anderl‐Straub, S
Rollin, A
Kuchcinski, G
Bertoux, M
Lebouvier, T
Benotmane, H
Deramecourt, V
Samra, K
Santiago, B
Masellis, M
de Mendonça, A
Duro, D
Leitão, MJ
Almeida, MR
Tábuas‐Pereira, M
Afonso, S
Engel, A
Polyakova, M
Russell, LL
Tagliavini, F
Butler, CR
Santana, I
Ber, IL
Gerhard, A
Olives, J
Ducharme, S
Swift, IJ
Levin, J
Danek, A
Bocchetta, M
Otto, M
Sorbi, S
Pasquier, F
Bouzigues, A
Russell, LL
Rohrer, JD
Redaelli, V
Rowe, JB
Rittman, T
Nicholas, J
Shafei, R
Esteve, AS
Nelson, A
Bouzigues, A
Heller, C
Greaves, CV
Cash, D
Thomas, DL
Convery, RS
Lladó, A
Timberlake, C
Cope, T
Rittman, T
Bertrand, A
Benussi, A
Rogaeva, E
Premi, E
Gasparotti, R
Archetti, S
Gazzina, S
Cantoni, V
Arighi, A
Antonell, A
Fenoglio, C
Borrego‐Ecija, S
Scarpini, E
Fumagalli, G
Castelo‐Branco, M
Borracci, V
Rossi, G
Giaccone, G
Di Fede, G
Caroppo, P
Tiraboschi, P
Prioni, S
Keywords: disease progression;frontotemporal dementia;functional magnetic resonance imaging (fMRI);network dynamics;presymptomatic
Issue Date: 15-Nov-2022
Publisher: Wiley on behalf of Alzheimer's Association
Citation: Whiteside, D.J. et al. (2022) 'Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia', Alzheimer's & Dementia, 0 (in press), pp. 1 - 16. doi: 10.1002/alz.12824.
Abstract: Copyright © 2022 The Authors. Introduction We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants. Discussion: Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion. Highlights: 1. We investigated brain network predictors of dementia symptom onset. 2. Frontotemporal dementia results in characteristic dynamic network patterns. 3. Alterations in network dynamics are associated with neuropsychological impairment. 4. Network dynamic changes predict symptomatic conversion in presymptomatic carriers. 5. Network dynamic changes are associated with longitudinal cognitive decline.
ISSN: 1552-5260
Other Identifiers: ORCID iD: Martina Bocchetta
Appears in Collections:Dept of Life Sciences Research Papers

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