Please use this identifier to cite or link to this item:
Title: Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022
Authors: Langan, LM
Paparella, M
Burden, N
Constantine, L
Margiotta‐Casaluci, L
Miller, T
Moe, SJ
Owen, SF
Schaffer, A
Sikanen, T
Keywords: in vitro;in vivo;new approach methods;risk assessment;fish;-omics;human;alternatives;3R models;pharmaceuticals;in silico modelling
Issue Date: 1-Feb-2023
Publisher: Wiley on behalf of Society of Environmental Toxicology and Chemistry
Citation: Langan, L.M. et al. (2023) 'Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022', Environmental Toxicology and Chemistry, 0 (accepted, in press), pp. 1 - 53. doi: 10.1002/etc.5578.
Abstract: In 2012, 20 key questions related to hazard and exposure assessment, and environmental and health risks of pharmaceuticals and personal care products (PPCPs) in the natural environment were identified. A decade later, this article examines the current level of knowledge around one of the lowest ranking questions at that time, number 19: “Can non–animal testing methods be developed that will provide equivalent or better hazard data compared with current in vivo methods?”. The inclusion of alternative methods that replace, reduce, or refine animal testing (the 3Rs) within the regulatory context of risk and hazard assessment of chemicals generally faces many hurdles, although this varies both by organism (human centric versus other), sector and geographical region or country. Focusing on the past 10 years, only works that might reasonably be considered to contribute to advancements in the field of aquatic environmental risk assessment, are highlighted. Particular attention is paid to methods of contemporary interest and importance, representing progress in a) the development of methods which provide equivalent or better data compared with current in vivo methods such as bioaccumulation, b) weight of evidence, or c) -omic based applications. Evolution and convergence of these risk assessment areas offer the basis for fundamental frame shifts in how data is collated and used for the protection of taxa across the breadth of the aquatic environment. Looking to the future, we are at a tipping point, with a need for a global and inclusive approach to establish consensus. Bringing together these methods (both new and old) for regulatory assessment and decision making will require a concerted effort and orchestration.
Description: Data Availability statement: No data has been generated in the writing of this article. However, all articles which have been cited or influenced the summarization outlined are provided in supplementary material on a section-by-section basis.
ISSN: 0730-7268
Other Identifiers: ORCID iDs: Laura M Langan; Lisa Constantine; Luigi Margiotta-Casaluci; Thomas Miller; Alexandra Schaffer; Tiina Sikanen
Appears in Collections:Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
FullTextAAM.pdf1.58 MBAdobe PDFView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.