Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/26333
Title: | Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19 |
Authors: | Davies, J Randeva, HS Chatha, K Hall, M Spandidos, DA Karteris, E Kyrou, I |
Keywords: | neuropilin-1;SarS-coV-2;coVid-19;brain;central nervous system;neurotropism;neurologic symptoms |
Issue Date: | 15-Sep-2020 |
Publisher: | Spandidos Publications |
Citation: | Davies, J. et al. (2020) 'Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19', Molecular Medicine Reports, 22 (5), pp. 4221 - 4226. doi: 10.3892/mmr.2020.11510. |
Abstract: | Copyright © 2020 Davies et al. Infection by the severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) is the cause of the new viral infectious disease (coronavirus disease 2019; COVID‑19). Emerging evidence indicates that COVID‑19 may be associated with a wide spectrum of neurological symptoms and complications with central nervous system (CNS) involvement. It is now well‑established that entry of SARS‑CoV‑2 into host cells is facilitated by its spike proteins mainly through binding to the angiotensin‑converting enzyme 2 (ACE‑2). Preclinical studies have suggested that neuropilin‑1 (NRP1), which is a transmembrane receptor that lacks a cytosolic protein kinase domain and exhibits high expression in the respiratory and olfactory epithelium, may also be implicated in COVID‑19 by enhancing the entry of SARS‑CoV‑2 into the brain through the olfactory epithelium. In the present study, we expand on these findings and demonstrate that the NRP1 is also expressed in the CNS, including olfactory‑related regions such as the olfactory tubercles and paraolfactory gyri. This furthers supports the potential role of NRP1 as an additional SARS‑CoV‑2 infection mediator implicated in the neurologic manifestations of COVID‑19. Accordingly, the neurotropism of SARS‑CoV‑2 via NRP1‑expressing cells in the CNS merits further investigation. |
Description: | Availability of data and materials: All data generated or analysed during this study are included in this published article. |
URI: | https://bura.brunel.ac.uk/handle/2438/26333 |
DOI: | https://doi.org/10.3892/mmr.2020.11510 |
ISSN: | 1791-2997 |
Other Identifiers: | ORCID iDs: Marcia Hall https://orcid.org/0000-0003-0039-5041; Emmanouil Karteris https://orcid.org/0000-0003-3231-7267 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright: © Davies et al. This is an open access article distributed under the terms of Creative Commons Attribution License.(https://creativecommons.org/licenses/by-nc-nd/4.0/) | 592.57 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License