Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/26575
Title: Mood disorder in idiopathic pulmonary fibrosis: response to pulmonary rehabilitation
Authors: Edwards, GD
Polgar, O
Patel, S
Barker, RE
Walsh, JA
Harvey, J
Man, WD-C
Nolan, CM
Issue Date: 22-May-2023
Publisher: European Respiratory Society (ERS)
Citation: Edwards, G.D. et al. (2023) 'Mood disorder in idiopathic pulmonary fibrosis: response to pulmonary rehabilitation', ERJ Open Research, 9 (3), 00585-2022, pp. 1 - 10. doi: 10.1183/23120541.00585-2022.
Abstract: Background: Pulmonary rehabilitation improves mood disorder in COPD, but there are limited data in idiopathic pulmonary fibrosis (IPF). The aims of this cohort study were to investigate whether pulmonary rehabilitation reduces mood disorder in IPF, and estimate the minimal important difference (MID) of the Hospital Anxiety and Depression Scale (HADS). Methods: HADS and core pulmonary rehabilitation outcomes were measured in 166 participants before and after an 8-week, in-person, outpatient pulmonary rehabilitation programme. Anchor- and distribution-based methods were used to calculate the MID of HADS-Anxiety (A) and HADS-Depression (D). Results: Suggestive or probable anxiety and depression (HADS ≥8) were present in 35% and 37% of participants, respectively, at baseline, and this reduced significantly following pulmonary rehabilitation (post-pulmonary rehabilitation: HADS-A 23%, HADS-D 26%). Overall, there was a significant reduction in HADS-D (mean change −1.1, 95% CI −1.6– −0.5), but not HADS-A (−0.6, −1.3–0.15) with pulmonary rehabilitation. Subgroup analysis of those with HADS ≥8 revealed significant improvements in HADS domains (mean change: HADS-A −4.5, 95% CI −5.7– −3.4; median change: HADS-D −4.0, interquartile range −6.0– −1.0). The mean (range) MID estimates for HADS-A and HADS-D were −2 (−2.3– −1.7) and −1.2 (−1.9– −0.5), respectively. Conclusion: In people with IPF and suggestive or probable mood disorder, pulmonary rehabilitation reduces anxiety and depression.
Description: Supplementary materials are available online at https://openres.ersjournals.com/content/9/3/00585-2022.figures-only#fig-data-supplementary-materials .
URI: https://bura.brunel.ac.uk/handle/2438/26575
DOI: https://doi.org/10.1183/23120541.00585-2022
Other Identifiers: ORCiD: William D-C. Man https://orcid.org/0000-0002-3782-659X
ORCiD: Claire M Nolan https://orcid.org/0000-0001-9067-599X
00585-2022
Appears in Collections:Dept of Health Sciences Research Papers

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