Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/26629
Title: | Fractional exhaled nitric oxide in the assessment of exercise-induced bronchoconstriction: a multicentre retrospective analysis of UK-based athletes |
Authors: | Dickinson, J Gowers, W Sturridge, S Williams, N Kippelen, P Simpson, A Jackson, A Hull, J Price, O |
Issue Date: | 4-Sep-2022 |
Publisher: | European Respiratory Society |
Citation: | Dickinson, J. et al. (2022) 'Fractional exhaled nitric oxide in the assessment of exercise-induced bronchoconstriction: a multicentre retrospective analysis of UK-based athletes', European Respiratory Journal, 60 (suppl. 66), 1017, pp. 1 - 2. doi: 10.1183/13993003.congress-2022.1017. |
Abstract: | Copyright © the authors 2022 Background: Exercise-induced bronchoconstriction (EIB) is a condition characterised by temporary lower airway narrowing that occurs in association with physical activity. FeNO is an indirect biomarker of type 2 airway inflammation that has an established role in the assessment of asthma. Aims: To evaluate the value of FeNO in the assessment of EIB. Method: Multicentre retrospective analysis. Four hundred and eighty-eight athletes (male: 76%) performed baseline FeNO and spirometry pre-and-post eucapnic voluntary hyperpnoea (EVH). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for established FeNO thresholds: intermediate (≥25ppb) and high (≥40 ppb and ≥50ppb) and evaluated against objective evidence of EIB (≥10% fall in FEV1). The diagnostic accuracy of FeNO was calculated using receiver operating characteristics area under the curve (ROC-AUC). Results: All athletes had normal resting lung function (>80% FEV1 pred). Despite this, 41% had a post-EVH fall in FEV1 consistent with EIB. FeNO values ≥25ppb, ≥40ppb and ≥50ppb were observed in 42%, 23% and 17% of the cohort, respectively. ROC-AUC for FeNO was 65%. Sensitivity, specificity, PPV and NPV are presented in Table 1. Conclusions: FeNO ≥40 ppb provides good specificity, i.e., ability to rule-in a diagnosis of EIB. However, due to the poor sensitivity and predictive values, FeNO should not be employed as a replacement for EVH. |
URI: | https://bura.brunel.ac.uk/handle/2438/26629 |
ISSN: | 0903-1936 |
Other Identifiers: | ORCID iD: John Dickinson https://orcid.org/0000-0002-1824-7402; Pascale Kippelen https://orcid.org/0000-0002-8443-0248. 1017 |
Appears in Collections: | Dept of Life Sciences Embargoed Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MeetingAbstract.pdf | Embargoed until 4 September 2023 | 144.96 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License