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Title: | Using next generation antimicrobials to target the mechanisms of infection |
Authors: | Gadar, K McCarthy, RR |
Issue Date: | 22-Sep-2023 |
Publisher: | Springer Nature |
Citation: | Gadar, K. and McCarthy, R. (2023) 'Using next generation antimicrobials to target the mechanisms of infection', npj Antimicrobials and Resistance, 1 (1), pp. 1 - 14. doi: 10.1038/s44259-023-00011-6. |
Abstract: | Copyright © The Author(s) 2023. The remarkable impact of antibiotics on human health is being eroded at an alarming rate by the emergence of multidrug resistant pathogens. There is a recognised consensus that new strategies to tackle infection are urgently needed to limit the devasting impact of antibiotic resistance on our global healthcare infrastructure. Next generation antimicrobials (NGAs) are compounds that target bacterial virulence factors to disrupt pathogenic potential without impacting bacterial viability. By disabling the key virulence factors required to establish and maintain infection, NGAs make pathogens more vulnerable to clearance by the immune system and can potentially render them more susceptible to traditional antibiotics. In this review, we discuss the developing field of NGAs and how advancements in this area could offer a viable standalone alternative to traditional antibiotics or an effective means to prolong antibiotic efficacy when used in combination. |
Description: | Competing interests: Brunel University London has priority patent fillings covering the therapeutic use of artificial sweeteners. |
URI: | https://bura.brunel.ac.uk/handle/2438/27373 |
DOI: | https://doi.org/10.1038/s44259-023-00011-6 |
Other Identifiers: | ORCID iD: Ronan R McCarthy https://orcid.org/0000-0002-7480-6352 11 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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