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|The baroreflex contribution to human cardiovascular control: Insight from passive exercise studies
|The contribution of muscle mechanoreflex to cardiovascular control;Control of circulation during passive exercise and postural shift;Regulation of heart rate, blood pressure and total peripheral resistance during and following passive exercise;The effects of passive exercise on muscle oxygenation and oxygen uptake;The influence of cardiac sympathovagal balance on baroreflex sensitivity
|Brunel University London
|The present thesis examined the affect of passive exercise on spontaneous baroreflex sensitivity (BRS) and cardiac syrnpathovagal balance. Other cardiovascular variables such heart rate (HR) and blood pressure (BP) were also assessed. Study 1 revealed that during passive exercise spontaneous BRS is decreased, the cardiac syrnpathovagal balance is shifted as a result a vagal withdrawal, and HR and BP increase in parallel. Study 2 investigated the interaction between postural shift and passive exercise on baroreflex control and HR. At rest, the postural shift from upright to supine resulted increased BRS and elicited bradycardia, while during both upright and supine passive exercise decreased BRS and elicited tachycardia. Study 3 showed that after passive exercise the cardiac vagal traffic was increased and HR was attenuated compared with pre-exercise. While, total peripheral resistance (TPR) increased, resulting in BP elevation. Study 4 showed that during passive exercise the local muscle tissue oxygenation increases despite the augmentation in oxygen uptake. In conclusion, the overall findings demonstrate that during passive exercise spontaneous BRS is decreased and the cardiac sympathovagal balance is shifted due to vagal withdrawal. The effects of passive exercise on BRS and HR override those of postural shift. After passive exercise cardiac vagal activity is enhanced and HR is reduced, while TPR and BP are elevated, presumably caused by increased vasoconstriction, as Q did not change. Also during passive exercise both muscle oxygenation and oxygen uptake increase.
|This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London
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Dept of Life Sciences Theses
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